Jorma Toppari profile picture
Jorma
Toppari
Professor, Institute of Biomedicine
InFLAMES Flagship
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Links

CV_Jorma_Toppari_ 2018_Nov.pdf
Publications J Toppari 2018 Nov.pdf
ORCID

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

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Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples (2022)

Epigenetics
Laajala Essi, Halla-Aho Viivi, Grönroos Toni, Kalim Ubaid Ullah, Vähä-Mäkilä Mari, Nurmio Mirja, Kallionpää Henna, Lietzén Niina, Mykkänen Juha, Rasool Omid, Toppari Jorma, Oresic Matej, Knip Mikael, Lund Riikka, Lahesmaa Riitta, Lähdesmäki Harri
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children (2022)

Pediatric Diabetes
Salami Falastin, Tamura Roy, You Lu, Lernmark Åke, Larsson Helena Elding, Lundgren Markus, Krischer Jeffrey, Ziegler Anette-Gabriele, Toppari Jorma, Veijola Riitta, Rewers Marian, Haller Michael J., Hagopian William, Akolkar Beena, Törn Carina; TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

INnoVative trial design for testing the Efficacy, Safety and Tolerability of 6-month treatment with incretin-based therapy to prevent type 1 DIAbetes in autoantibody positive participants: A protocol for three parallel double-blind, randomised controlled trials (INVESTDIA) (2022)

Diabetic Medicine
Kero Jukka, Koskenniemi Jaakko J., Karsikas Sara, Pokka Tytti, Lou Olivia, Toppari Jorma, Veijola Riitta
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Heterogeneity of beta-cell function in subjects with multiple islet autoantibodies in the TEDDY family prevention study - TEFA (2022)

Martinez Maria Månsson, Spiliopoulos Lampros, Salami Falastin, Agardh Daniel, Toppari Jorma, Lernmark Åke, Kero Jukka, Veijola Riitta, Tossavainen Päivi, Palmu Sauli, Lundgren Markus, Borg Henrik, Katsarou Anastasia, Larsson Helena Elding, Knip Mikael, Maziarz Marlena, Törn Carina; and the TEDDY-Family (TEFA) Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes (2021)

Diabetes Care
Nurminen Noora, Cerrone Damiano, Lehtonen Jussi, Parajuli Anirudra, Roslund Marja, Lonnrot Maria, Ilonen Jorma, Toppari Jorma, Veijola Riitta, Knip Mikael, Rajaniemi Juho, Laitinen Olli H., Sinkkonen Aki, Hyöty Heikki
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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