Jorma Toppari profile picture
Jorma
Toppari
Professor, Institute of Biomedicine
InFLAMES Flagship
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Links

CV_Jorma_Toppari_ 2018_Nov.pdf
Publications J Toppari 2018 Nov.pdf
ORCID

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

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RANKL regulates male reproductive function (2021)

Nature Communications
Jensen MB, Andreassen CH, Jorgensen A, Nielsen JE, Mortensen L, Boisen IM, Schwarz P, Toppari J, Baron R, Lanske B, Juul A
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes (2021)

Diabetes Care
Nurminen Noora, Cerrone Damiano, Lehtonen Jussi, Parajuli Anirudra, Roslund Marja, Lonnrot Maria, Ilonen Jorma, Toppari Jorma, Veijola Riitta, Knip Mikael, Rajaniemi Juho, Laitinen Olli H., Sinkkonen Aki, Hyöty Heikki
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Consumption of differently processed milk products in infancy and early childhood and the risk of islet autoimmunity (2020)

British Journal of Nutrition
Katariina Koivusaari, Essi Syrjälä, Sari Niinistö, Hanna-Mari Takkinen, Suvi Ahonen, Mari Åkerlund, Tuuli E. Korhonen, Jorma Toppari, Jorma Ilonen, Jaakko Peltonen, Jaakko Nevalainen, Mikael Knip, Tapani Alatossava, Riitta Veijola, Suvi M. Virtanen
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: The TEDDY study (2020)

Gut
Katri Lindfors, Jake Lin, Hye-Seung Lee, Heikki Hyöty, Matti Nykter, Kalle Kurppa, Edwin Liu, Sibylle Koletzko, Marian Rewers, William Hagopian, Jorma Toppari, Annette-Gabriele Ziegler, Beena Akolkar, Jeffrey P Krischer, Joseph F Petrosino, Richard E Lloyd, Daniel Agardh; the TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

A combined risk score enhances prediction of type 1 diabetes among susceptible children (2020)

Nature Medicine
Lauric A. Ferrat , Kendra Vehik , Seth A. Sharp, Åke Lernmark , Marian J. Rewers, Jin-Xiong She, Anette-G. Ziegler, Jorma Toppari, Beena Akolkar, Jeffrey P. Krischer, Michael N. Weedon1, Richard A. Oram, William A. Hagopian; TEDDY Study Group & Committees
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
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