Jorma Toppari profile picture
Jorma
Toppari
Professor, Institute of Biomedicine
InFLAMES Flagship
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Links

CV_Jorma_Toppari_ 2018_Nov.pdf
Publications J Toppari 2018 Nov.pdf
ORCID

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

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Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2 ',3,4,4 ',5,5 '-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats (2021)

Reproductive Toxicology
Alarcon Sonia, Esteban Javier, Roos Robert, Heikkinen Päivi, Sanchez-Perez Ismael, Adamsson Annika, Toppari Jorma, Koskela Antti, Finnilä Mikko AJ, Tuukkanen Juha, Herlin Maria, Hamscher Gerd, Leslie Heather A, Korkalainen Merja, Halldin Krister, Schrenk Dieter, Håkansson Helen, Viluksela Matti
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

TEDDY luo toivoa (2021)

Diabetes ja lääkäri
Toppari Jorma, Knip Mikael, Kurppa Kalle, Hyöty Heikki, Ilonen Jorma, Veijola Riitta, Virtanen Suvi M.
(Artikkeli ammattilehdessä tai kirjoitus ammatillisessa blogissa (D1))

RUBIC (ReproUnion Biobank and Infertility Cohort): A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity (2021)

Andrology
Priskorn Lærke, Tøttenborg Sandra Søgaard, Almstrup Kristian, Andersson Anna-Maria, Axelsson Jonatan, Bräuner Elvira Vaclavik, Elenkov Angel, Freiesleben Nina la Cour, Giwercman Yvonne Lundberg, Grøndahl Marie Louise, Hansen Ann Holm, Hansen Laura Smidt, Henic Emir, Kitlinski Margareta Laczna, Landersoe Selma Kloeve, Lindh Christian, Løkkegaard Ellen Leth, Malm Johan, Olsen Kristina Wendelboe, Petersen Kajsa Uglevig, Schmidt Lone, Stormlund Sacha, Svendsen Pernille Fog, Vassard Ditte, Wang Nathalie Friis, Zedeler Anne, Bhasin Shalender, Chavarro Jorge, Eisenberg Michael L., Hauser Russ, Huhtaniemi Ilpo, Krawetz Stephen A., Marko-Varga György, Salonia Andrea, Toppari Jorma, Juul Anders, Jørgensen Niels, Nielsen Henriette Svarre, Pinborg Anja, Rylander Lars, Giwercman Aleksander
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Lapsen epäselvän sukupuolen diagnostiikka ja hoito (2021)

Duodecim
Kohva Ella, Holopainen Elina, Huopio Hanna, Keskinen Päivi, Ojaniemi Marja, Taskinen Seppo, Toppari Jorma, Raivio Taneli, Miettinen Päivi J
(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))

Children's erythrocyte fatty acids are associated with the risk of islet autoimmunity (2021)

Scientific Reports
Niinistö Sari, Erlund Iris, Lee Hye-Seung, Uusitalo Ulla, Salminen Irma, Aronsson Carin Andén, Parikh Hemang M, Liu Xiang, Hummel Sandra, Toppari Jorma, She Jin-Xiong, Lernmark Åke, Ziegler Annette G, Rewers Marian, Akolkar Beena, Krischer Jeffrey P, Galas David, Das Siba, Sakhanenko Nikita, Rich Stephen S, Hagopian William, Norris Jill M, Virtanen Suvi M; the TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Islet Autoimmunity and HLA Markers of Presymptomatic and Clinical Type 1 Diabetes: Joint Analyses of Prospective Cohort Studies in Finland, Germany, Sweden, and the US (2021)

Diabetes Care
Anand Vibha, Li Ying, Liu Bin, Ghalwash Mohamed, Koski Eileen, Ng Kenney, Dunne Jessica L., Jonsson Josefine, Winkler Christiane, Knip Mikael, Toppari Jorma, Ilonen Jorma, Killian Michael B., Frohnert Brigitte I., Lundgren Markus, Ziegler Anette-Gabriele, Hagopian William, Veijola Riitta, Rewers Marian; for the T1DI Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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