Jorma Toppari profile picture
Jorma
Toppari
Professor, Institute of Biomedicine
InFLAMES Flagship
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

Sort by:

Associations of breastfeeding with childhood autoimmunity, allergies, and overweight: The Environmental Determinants of Diabetes in the Young (TEDDY) study (2021)

American Journal of Clinical Nutrition
Hummel Sandra, Weiss Andreas, Bonifacio Ezio, Agardh Daniel, Akolkar Beena, Aronsson Carin A, Hagopian William A, Koletzko Sibylle, Krischer Jeffrey P, Lernmark Ake, Lynch Kristian, Norris Jill M, Rewers Marian J, She Jin-Xiong, Toppari Jorma, Uusitalo Ulla, Vehik Kendra, Virtanen Suvi M, Beyerlein Andreas, Ziegler Anette-G
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Placenta is Capable of Protecting the Male Fetus from Exposure to Environmental Bisphenol A (2021)

Exposure and Health
Lukasiewicz Monika, Czerniecki Jan, Ponikwicka-Tyszko Donata, Sztachelska Maria, Hryniewicka Marta, Nalewajko-Sieliwoniuk Edyta, Wiczkowski Wieslaw, Banaszewska Beata, Milewski Robert, Toppari Jorma, Huhtaniemi Ilpo, Rahman Nafis A., Wolczynski Slawomir
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Sukupuolen kehityksen biologia ja genetiikka (2021)

Duodecim
Kohva Ella, Holopainen Elina, Huopio Hanna, Keskinen Päivi, Ojaniemi Marja, Taskinen Seppo, Toppari Jorma, Raivio Taneli, Miettinen Päivi J
(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))

Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2 ',3,4,4 ',5,5 '-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats (2021)

Reproductive Toxicology
Alarcon Sonia, Esteban Javier, Roos Robert, Heikkinen Päivi, Sanchez-Perez Ismael, Adamsson Annika, Toppari Jorma, Koskela Antti, Finnilä Mikko AJ, Tuukkanen Juha, Herlin Maria, Hamscher Gerd, Leslie Heather A, Korkalainen Merja, Halldin Krister, Schrenk Dieter, Håkansson Helen, Viluksela Matti
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Children's erythrocyte fatty acids are associated with the risk of islet autoimmunity (2021)

Scientific Reports
Niinistö Sari, Erlund Iris, Lee Hye-Seung, Uusitalo Ulla, Salminen Irma, Aronsson Carin Andén, Parikh Hemang M, Liu Xiang, Hummel Sandra, Toppari Jorma, She Jin-Xiong, Lernmark Åke, Ziegler Annette G, Rewers Marian, Akolkar Beena, Krischer Jeffrey P, Galas David, Das Siba, Sakhanenko Nikita, Rich Stephen S, Hagopian William, Norris Jill M, Virtanen Suvi M; the TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Beta cell function in participants with single or multiple islet autoantibodies at baseline in the TEDDY Family Prevention Study: TEFA (2021)

Endocrinology, Diabetes and Metabolism
Martinez Maria Månsson, Salami Falastin, Larsson Helena Elding, Toppari Jorma, Lernmark Åke, Kero Jukka, Veijola Riitta, Koskenniemi Jaakko J., Tossavainen Päivi, Lundgren Markus, Borg Henrik, Katsarou Anastasia, Maziarz Marlena, Törn Carina; The TEDDY Family (TEFA) Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))