Jorma Toppari profile picture
Jorma
Toppari
Professor, Institute of Biomedicine
InFLAMES Flagship
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Links

CV_Jorma_Toppari_ 2018_Nov.pdf
Publications J Toppari 2018 Nov.pdf
ORCID

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

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Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity (2023)

Cell Reports Medicine
Nakayasu E.S., Bramer L.M., Ansong C., Schepmoes A.A., Fillmore T.L., Gritsenko M.A., Clauss T.R., Gao Y., Piehowski P.D., Stanfill B.A., Engel D.W., Orton D.J., Moore R.J., Qian W.J., Sechi S., Frohnert B.I., Toppari J., Ziegler A.G., Lernmark Å., Hagopian W., Akolkar B., Smith R.D., Rewers M.J., Webb-Robertson B.J.M., Metz T.O.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Longitudinal consumption of fruits and vegetables and risk of asthma by 5 years of age (2023)

Pediatric Allergy and Immunology
Metsälä Johanna, Vuorinen Anna-Leena, Takkinen Hanna-Mari, Peltonen Essi J., Ahonen Suvi, Åkerlund Mari, Tapanainen Heli, Mattila Markus, Toppari Jorma, Ilonen Jorma, Veijola Riitta, Haahtela Tari, Knip Mikael, Kaila Minna, Virtanen Suvi M.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Evaluation of plasma IL-21 as a potential biomarker for type 1 diabetes progression (2023)

Frontiers in Immunology
Schroderus Anna-Mari, Poorbaugh Josh, McElyea Samantha, Beasley Stephanie, Zhang Lin, Näntö-Salonen Kirsti, Rintamäki Reeta, Pihlajamäki Jussi, Knip Mikael, Veijola Riitta, Toppari Jorma, Ilonen Jorma, Benschop Robert J., Kinnunen Tuure
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Novel Expression of Zona Pellucida 3 Protein in Normal Testis; Potential Functional Implications (2022)

Molecular and Cellular Endocrinology
Pulawska Kamila, Ponikwicka-Tyszko Donata, Lebiedzinska Weronika, Guo Peilan, Bernaczyk Piotr, Pilaszewicz-Puza Agata, Li Xiangdong, Chrusciel Marcin, Lupu Oana, Leskinen Sini, Mäkelä Juho-Antti, Toppari Jorma, Wolczynski Slawomir, Coelingh BenninkHerjan J.T., Huhtaniemi Ilpo, Rahman Nafis A.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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