Jorma Toppari profile picture
Jorma
Toppari
Professor, Institute of Biomedicine
InFLAMES Flagship
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Links

CV_Jorma_Toppari_ 2018_Nov.pdf
Publications J Toppari 2018 Nov.pdf
ORCID

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

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Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs (2024)

Nature
Tomar, A.; Gomez-Velazquez, M.; Gerlini, R.; Comas-Armangué, G.; Makharadze, L.; Kolbe, T.; Boersma, A.; Dahlhoff, M.; Burgstaller, J. P.; Lassi, M.; Darr, J.; Toppari, J.; Virtanen, H.; Kühnapfel, A.; Scholz, M.; Landgraf, K.; Kiess, W.; Vogel, M.; Gailus-Durner, V.; Fuchs, H.; Marschall, S.; Hrabě de Angelis, M.; Kotaja, N.; Körner, A.; Teperino, R.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study (2024)

European Journal of Nutrition
Hakola Leena, Mramba Lazarus K., Uusitalo Ulla, Andrén Aronsson Carin, Hummel Sandra, Niinistö Sari, Erlund Iris, Yang Jimin, Rewers Marian J., Akolkar Beena, McIndoe Richard A., Rich Stephen S., Hagopian William A., Ziegler Anette, Lernmark Åke, Toppari Jorma, Krischer Jeffrey P., Norris Jill M., Virtanen Suvi M.; The TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

The Influence of Pubertal Development on Autoantibody Appearance and Progression to Type 1 Diabetes in the TEDDY Study (2024)

Journal of the Endocrine Society
Warncke, Katharina; Tamura, Roy; Schatz, Desmond A; Veijola, Riitta; Steck, Andrea K; Akolkar, Beena; Hagopian, William; Krischer, Jeffrey P; Lernmark, Åke; Rewers, Marian J; Toppari, Jorma; McIndoe, Richard; Ziegler, Anette-G; Vehik, Kendra; Haller, Michael J; Elding Larsson, Helena
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
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