Jorma Toppari profile picture
Jorma
Toppari
Professor, Institute of Biomedicine
InFLAMES Flagship
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Links

CV_Jorma_Toppari_ 2018_Nov.pdf
Publications J Toppari 2018 Nov.pdf
ORCID

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

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Incidence of Pediatric Celiac Disease Varies by Region (2023)

American Journal of Gastroenterology
Stahl Marisa, Li Qian, Lynch Kristian, Koletzko Sibylle, Mehta Pooja, Gragert Loren, Norris Jill M, Andrén Aronsson Carin, Lindfors Katri, Kurppa Kalle, Ilonen Jorma, Krischer Jeffrey, Alkolkar Beena, Ziegler Anette-G, Toppari Jorma, Rewers Marian J, Agardh Daniel, Hagopian William, Liu Edwin; TEDDY Study Group
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection (2023)

Nature Communications
Lin Jake, Moradi Elaheh, Salenius Karoliina, Lehtipuro Suvi, Häkkinen Tomi, Laiho Jutta E., Oikarinen Sami, Randelin Sofia, Parikh Hemang M., Krischer Jeffrey P., Toppari Jorma, Lernmark Åke, Petrosino Joseph F., Ajami Nadim J., She Jin-Xiong, Hagopian William A., Rewers Marian J., Lloyd Richard E., Rautajoki Kirsi J., Hyöty Heikki, Nykter Matti; the TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Dietary Intake and Body Mass Index Influence the Risk of Islet Autoimmunity in Genetically At-Risk Children: A Mediation Analysis Using the TEDDY Cohort (2023)

Pediatric Diabetes
Aronsson Carin Andren, Tamura Roy, Vehik Kendra, Uusitalo Ulla, Yang Jimin, Haller Michael J., Toppari Jorma, Hagopian William, McIndoe Richard A., Rewers Marian J., Ziegler Anette-G., Akolkar Beena, Krischer Jefrey P., Norris Jill M., Virtanen Suvi M., Larsson Helena Elding
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study (2023)

Diabetes Care
Thorsen Steffen U., Liu Xiang, Kataria Yachana, Mandrup-Poulsen Thomas, Kaur Simranjeet, Uusitalo Ulla, Virtanen Suvi M., Norris Jill M., Rewers Marian, Hagopian William, Yang Jimin, She Jin-Xiong, Akolkar Beena, Andrén Aronsson Carin, Lernmark Åke, Ziegler Anette-Gabriele, Toppari Jorma, Krischer Jeffrey, Parikh Hemang M., Ellervik Christina, Svensson Jannet; TEDDY Study Group
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study (2023)

PLoS ONE
Mehta Pooja, Li Qian, Stahl Marisa, Uusitalo Ulla, Lindfors Katri, Butterworth Martha D, Kurppa Kalle, Virtanen Suvi, Koletzko Sibylle, Aronsson Carin, Hagopian William A, Rewers Marian J, Toppari Jorma, Ziegler Anette-G, Akolkar Beena, Krischer Jeffrey P, Agardh Daniel, Liu Edwin, TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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