Novel Genetic Variant with Implications on Heart Failure Pathogenesis Identified
Finnish researchers have identified an exonic variant in the TRIM55 gene, which affects cardiomyocyte specific functions and reduces cardiac contractility.
Finnish researchers have identified an exonic variant in the TRIM55 gene, which affects cardiomyocyte specific functions and reduces cardiac contractility.
Focal adhesions are known as signalling platforms broadcasting the information of the biochemical and physical qualities of the extracellular matrix into intracellular signalling cascades. However, focal adhesions remain unstudied in the context of human pluripotent stem cells.
Turku Bioscience Centre, or Turku Bioscience in short, a joint unit of the University of Turku and Åbo Akademi University offering technology services and producing top research in biosciences is celebrating its 30th anniversary this year. On Wednesday 2 October, the Centre celebrated this with a seminar showcasing its achievements throughout the years.
Jane and Aatos Erkko Foundation has awarded 1.7 million euros for T-cell research that is led by academy professor Riitta Lahesmaa.
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Researchers from the Turku Bioscience Centre have found changes in molecules in the blood that might be new markers of type 1 diabetes. The new findings may help understand the early pathogenesis of the disease.
Enteroviral infections are common viral infections with usually rather few symptoms, and they are also believed to be linked to the onset of type 1 diabetes. Type 1 diabetes is a disorder in which the pancreatic insulin-producing beta-cells are destroyed, and it is more common in Finland than anywhere else in the world.
Among all the branches of life sciences, cell and molecular biology have often relied upon the development of key enabling technologies. Several significant paradigm shifts in biosciences have their origins specifically in novel and innovative technologies and/or methods.
Using cutting-edge genomics methods a gene signature predicting type 1 diabetes was discovered. This signature is detectable already before the appearance of type 1 diabetes associated autoantibodies. The finding could help in identifying early on the children who are likely to develop the disease later.
Common and rare SORLA single nucleotide polymorphisms have been associated with the development of Alzheimer’s disease. So far, SORLA has been mainly studied in neurons, but the new study focused on the role of SORLA in cancer cells. Led by Academy Professor Johanna Ivaska, the research group observed that SORLA was highly expressed in HER2 positive cancers. Removing SORLA from cancer cells severely impaired the oncogenic fitness of HER2 positive cancers.