Olli
Pentikäinen
Professor, Institute of Biomedicine
InFLAMES Flagship
PhD
Links
Areas of expertise
Computer-Dependent Drug Discovery
Molecular Modeling
Protein structure-function relationship
Protein-protein interaction
Biography
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Research
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
Publications
Novel analogs and stereoisomers of the marine toxin neodysiherbaine with specificity for kainate receptors (2008)
Journal of Pharmacology and Experimental Therapeutics
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Cooperative symmetric to asymmetric conformational transition of the apo-form of scavenger decapping enzyme revealed by simulations (2008)
Proteins
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Novel analogs and stereoisomers of the marine toxin neodysiherbaine with specificity for kainate receptors (2008)
Journal of Pharmacology and Experimental Therapeutics
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Cooperative symmetric to asymmetric conformational transition of the apo-form of scavenger decapping enzyme revealed by simulations (2008)
Proteins
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Development and characterization of GluR5 kainate receptor antagonists (2007)
Journal of Neurochemistry
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding (2007)
EMBO Journal
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Synthesis and pharmacological characterization of N-3-substituted willardiine derivatives: Role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLU(K5) kainate receptor antagonists (2007)
Journal of Medicinal Chemistry
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Development and characterization of GluR5 kainate receptor antagonists (2007)
Journal of Neurochemistry
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Synthesis and pharmacological characterization of N-3-substituted willardiine derivatives: Role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLU(K5) kainate receptor antagonists (2007)
Journal of Medicinal Chemistry
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Subtype selectivity and flexibility of ionotropic glutamate receptors upon antagonist ligand binding (2006)
Organic and Biomolecular Chemistry
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))