Nafis Rahman profile picture
Nafis
Rahman
Docent, Faculty of Medicine
Clinical Lecturer, Institute of Biomedicine
MD, PhD

Contact

+358 29 450 4637
+358 50 477 3022
Kiinamyllynkatu 10
20520
Turku

Links

Rahman publ 2020.pdf
ORCID

Areas of expertise

endocrine-related cancer
gonadotropins
hypothalamus-pituitary-gonadal axis
ardenocortical tumours
novel treatment strategies

Biography

Docent of Physiology, University of Turku, Turku, Finland (2005)  & Docent of Medicine, Medical University of Bialystok, Poland (2016); Doctor of Medical Sciences (Ph.D.), Medical University of Lodz, Poland  (1995); Specialization in Obstetrics & Gynecology, Medical University of Lodz, Poland  (1995); Licentiate in Medicine, Medical University of Lodz, Poland  (1991)

Working at the University of Turku: from 1996 - 

Postdoctoral training: Prof Ilpo Huhtaniemi group 1996 - 1998

Visiting professorships  Current: Medical University of Bialystok, Bialystok, Poland; Former: FIU College of Medicine, Miami, FL, USA

Editor in chief from 2016 https://www.journals.elsevier.com/reproductive-biology/

Teaching

Teach at the University of Turku, Faculty of Medicine, medical curriculum students: Physiology, Endocrinology, reproductive Endocrinology; Reproductive Biology courses

Received the teacher of the year award (Vuoden Opettaja) in 2005 from the Student Union & Rector of the University of Turku.

Research

Our study the underlying molecular mechanisms of hormonally regulated cancers (i.e. prostate, ovarian, testicular and adrenocortical), search for their novel biomarkers and treatment. We recently tested the potential of tumor specific zona pellucida antigen-3 immunization to enhance therapeutic effects in several hormonally regulated cancers. We have used successfully conjugated lytic peptides to eradicate only cancer cells through their specific gonadotropin receptors (such as lhcgr). We use transgenic murine endocrine cancer metastatic disease models and immortalized cell lines to test the feasibility of novel treatment strategies starting at cellular, in vivo in TG mice and finally aim for human clinical trials. 

Publications

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Human pluripotent stem cell-derived cells endogenously expressing follicle-stimulating hormone receptors: modeling the function of an inactivating receptor mutation (2022)

Molecular Human Reproduction
Lundin K, Sepponen K, Väyrynen P, Liu X, Yohannes DA, Survila M, Ghimire B, Känsäkoski J, Katayama S, Partanen J, Vuoristo S, Paloviita P, Rahman N, Raivio T, Luiro K, Huhtaniemi I, Varjosalo M, Tuuri T, Tapanainen JS
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Placenta is Capable of Protecting the Male Fetus from Exposure to Environmental Bisphenol A (2021)

Exposure and Health
Lukasiewicz Monika, Czerniecki Jan, Ponikwicka-Tyszko Donata, Sztachelska Maria, Hryniewicka Marta, Nalewajko-Sieliwoniuk Edyta, Wiczkowski Wieslaw, Banaszewska Beata, Milewski Robert, Toppari Jorma, Huhtaniemi Ilpo, Rahman Nafis A., Wolczynski Slawomir
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance (2021)

Nature Communications
Qin Yongli, Jia Lina, Liu Huijiao, Ma Wenqiang, Ren Xinmin, Li Haifeng, Liu Yuanwu, Li Haiwen, Ma Shuoqian, Liu Mei, Li Pingping, Yan Jinghua, Zhang Jiyan, Guo Yangdong, You Hua, Guo Yan, Rahman Nafis A., Wolczynski Slawomir, Kretowski Adam, Li Dangsheng, Li Xiru, Ren Fazheng, Li Xiangdong
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

GnRH antagonist treatment of malignant adrenocortical tumors (2019)

Endocrine-Related Cancer
Doroszko M, Chrusciel M, Stelmaszewska J, Slezak T, Anisimowicz S, Plöckinger U, Quinkler M, Bonomi M, Wolczynski S, Huhtaniemi I, Toppari J, Rahman NA
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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