Nafis Rahman profile picture
Nafis
Rahman
Docent, Faculty of Medicine
Clinical Lecturer, Institute of Biomedicine
MD, PhD

Contact

+358 29 450 4637
+358 50 477 3022
Kiinamyllynkatu 10
20520
Turku

Links

Rahman publ 2020.pdf
ORCID

Areas of expertise

endocrine-related cancer
gonadotropins
hypothalamus-pituitary-gonadal axis
ardenocortical tumours
novel treatment strategies

Biography

Docent of Physiology, University of Turku, Turku, Finland (2005)  & Docent of Medicine, Medical University of Bialystok, Poland (2016); Doctor of Medical Sciences (Ph.D.), Medical University of Lodz, Poland  (1995); Specialization in Obstetrics & Gynecology, Medical University of Lodz, Poland  (1995); Licentiate in Medicine, Medical University of Lodz, Poland  (1991)

Working at the University of Turku: from 1996 - 

Postdoctoral training: Prof Ilpo Huhtaniemi group 1996 - 1998

Visiting professorships  Current: Medical University of Bialystok, Bialystok, Poland; Former: FIU College of Medicine, Miami, FL, USA

Editor in chief from 2016 https://www.journals.elsevier.com/reproductive-biology/

Teaching

Teach at the University of Turku, Faculty of Medicine, medical curriculum students: Physiology, Endocrinology, reproductive Endocrinology; Reproductive Biology courses

Received the teacher of the year award (Vuoden Opettaja) in 2005 from the Student Union & Rector of the University of Turku.

Research

Our study the underlying molecular mechanisms of hormonally regulated cancers (i.e. prostate, ovarian, testicular and adrenocortical), search for their novel biomarkers and treatment. We recently tested the potential of tumor specific zona pellucida antigen-3 immunization to enhance therapeutic effects in several hormonally regulated cancers. We have used successfully conjugated lytic peptides to eradicate only cancer cells through their specific gonadotropin receptors (such as lhcgr). We use transgenic murine endocrine cancer metastatic disease models and immortalized cell lines to test the feasibility of novel treatment strategies starting at cellular, in vivo in TG mice and finally aim for human clinical trials. 

Publications

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Functional evidence for two distinct mechanisms of action of progesterone and selective progesterone receptor modulator on uterine leiomyomas (2024)

Fertility and Sterility
Milewska Gabriela, Ponikwicka–Tyszko Donata, Bernaczyk Piotr, Lupu Oana, Szamatowicz Michal, Sztachelska Maria, Pilaszewicz-Puza Agata, Koda Mariusz, Bielawski Tomasz, Zbucka-Kretowska Monika, Pawelczyk Adam, Tomaszewski Jakub, Li Xiangdong, Huhtaniemi Ilpo, Wolczynski Slawomir, Rahman Nafis A.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Novel ectopic expression of zona pellucida 3 glycoprotein in lung cancer promotes tumor growth (2024)

International Journal of Cancer
Pulawska-Moon, Kamila; Ponikwicka-Tyszko, Donata; Lebiedzinska, Weronika; Pilaszewicz-Puza, Agata; Bernaczyk, Piotr; Koda, Mariusz; Lupu, Oana; Milewska, Gabriela; Huang, Chen-Che Jeff; Zheng, Huifei; Schiele, Phillip; Na, Il-Kang; Frentsch, Marco; Li, Xiangdong; Toppari, Jorma; Wolczynski, Slawomir; Coelingh Bennink, Herjan J. T.; Huhtaniemi, Ilpo; Rahman, Nafis A.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Congenital Hypothyroidism and Hyperthyroidism Alters Adrenal Gene Expression, Development, and Function (2022)

Thyroid
Patyra Konrad, Löf Christoffer, Jaeschke Holger, Undeutsch Hendrik, Zheng Huifei Sophia, Tyystjärvi Sofia, Puławska Kamila, Doroszko Milena, Chruściel Marcin, Loo Britt-Marie, Kurkijärvi Riikka, Zhang Fu-Ping, Huang Chen-Che Jeff, Ohlsson Claes, Kero Andreina, Poutanen Matti, Toppari Jorma, Paschke Ralf, Rahman Nafis, Huhtaniemi Ilpo, Jääskeläinen Jarmo, Kero Jukka
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Human pluripotent stem cell-derived cells endogenously expressing follicle-stimulating hormone receptors: modeling the function of an inactivating receptor mutation (2022)

Molecular Human Reproduction
Lundin K, Sepponen K, Väyrynen P, Liu X, Yohannes DA, Survila M, Ghimire B, Känsäkoski J, Katayama S, Partanen J, Vuoristo S, Paloviita P, Rahman N, Raivio T, Luiro K, Huhtaniemi I, Varjosalo M, Tuuri T, Tapanainen JS
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Novel Expression of Zona Pellucida 3 Protein in Normal Testis; Potential Functional Implications (2022)

Molecular and Cellular Endocrinology
Pulawska Kamila, Ponikwicka-Tyszko Donata, Lebiedzinska Weronika, Guo Peilan, Bernaczyk Piotr, Pilaszewicz-Puza Agata, Li Xiangdong, Chrusciel Marcin, Lupu Oana, Leskinen Sini, Mäkelä Juho-Antti, Toppari Jorma, Wolczynski Slawomir, Coelingh BenninkHerjan J.T., Huhtaniemi Ilpo, Rahman Nafis A.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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