Leena Kainulainen profile picture
Leena
Kainulainen
Docent, Paediatrics and Adolescent Medicine

Contact

Areas of expertise

paediatrics
immunodeficiency
paediatric infectious diseases
respiratory infections
rhinovirus

Biography

Docent Leena Kainulainen graduated from medical school in 1995(University of Turku) and defended her PhD theses on CVID in 2000. She received specialist licence in paediatrics in 2005 and in pediatric infectious diseases 2013 and was appointed as a docent in paediatrics in 2013 (University of Turku). She is currently working as Head of the Division of Pediatric Care in Turku University Hospital and as an immunology consultant at Department of Pediatrics and Medicine at Turku University Hospital. She participates in neonatal screening for severe immunodeficiencies.


Teaching

Docent Kainulainen has been working as a clinical lecturer in pediatrics 2004 and 2006. Currently she teaches regularly medical students and paediatric residents as a part of her clinical duties.


Research

Docent Kainulainen´s research is  focused on primary immunodeficiency. Her current research interests comprise rhinovirus infections in primary hypogammaglobulinemia patients. Clinical trial on the treatment of rhinovirus infection with pegylated interferon alfa in CVID patients is ongoing. Research project on innate immunity in autoimmune patients is ongoing. In addition, she participates in research project aiming at  evaluating immunological status in pediatric patients with neonatal cardiac surgery.


Publications

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Wiskott-Aldrich Syndrome: A study on 577 patients defining the genotype as a predictive biomarker for disease severity (2024)

Blood
Vallée Tanja C, Glasmacher Jannik S, Buchner Hannes, Arkwright Peter D, Behrends Uta, Bondarenko Anastasia, Browning Michael J, Buchbinder David K, Cattoni Alessandro, Chernyshova Liudmyla, Ciznar Peter, Cole Theresa, Czogala Wojciech, Dueckers Gregor, Edgar John David M, Erbey Fatih, Fasth Anders, Ferrua Francesca, Formankova Renata, Gambineri Eleonora, Gennery Andrew R, Goldman Frederick D, Gonzalez-Granado Luis Ignacio, Heilmann Carsten, Heiskanen-Kosma Tarja, Juntti Hanna, Kainulainen Leena, Kanegane Hirokazu, Karaca Neslihan E., Sebnem Kilic Sara, Klein Christoph, Koltan Sylwia MD PhD, Kondratenko Irina, Meyts Isabelle, Nasrullayeva Gulnara M, Notarangelo Lucia Dora, Pasic Srdjan, Pellier Isabelle, Pignata Claudio, Misbah Siraj Ahmed, Schulz Ansgar S, Segundo Gesmar RS, Shcherbina Anna, Slatter Mary A, Sokolic Robert, Soler-Palacin Pere, Stepensky Polina, van Montfrans Joris M., Ryhänen Samppa, Wolska-Kuśnierz Beata MD PhD, Ziegler John B, Zhao Xiaodong, Aiuti Alessandro, Ochs Hans D, Albert Michael H
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome (2022)

Journal of Allergy and Clinical Immunology
Leiding Jennifer W, Vogel Tiphanie P, Santarlas Valentine GJ, Mhaskar Rahul, Smith Madison R, Carisey Alexandre, Vargas-Hernández Alexander, Silva-Carmona Manuel, Heeg Maximilian, Rensing-Ehl Anne, Neven Bénédicte, Hadjadj Jérôme, Hambleton Sophie, Ronan Leahy Timothy, Meesilpavikai Kornvalee, Cunningham-Rundles Charlotte, Dutmer Cullen M, Sharapova Svetlana O, Taskinen Mervi, Chua Ignatius, Hague Rosie, Klemann Christian, Kostyuchenko Larysa, Morio Tomohiro, Thatayatikom Akaluck, Ozen Ahmet, Scherbina Anna, Bauer Cindy S, Flanagan Sarah E, Gambineri Eleonora, Giovannini-Chami Lisa, Heimall Jennifer, Sullivan Kathleen E, Allenspach Eric, Romberg Neil, Deane Sean G, Prince Benjamin T, Rose Melissa J, Bohnsack John, Mousallem Talal, Jesudas Rohit, Santos Vilela Maria Marluce Dos, O'Sullivan Michael, Pachlopnik Schmid Jana, Průhová Štěpánka, Klocperk Adam, Rees Matthew, Su Helen, Bahna Sami, Baris Safa, Bartnikas Lisa M, Chang Berger Amy, Briggs Tracy A, Brothers Shannon, Bundy Vanessa, Chan Alice Y, Chandrakasan Shanmuganathan, Christiansen Mette, Cole Theresa, Cook Matthew C, Desai Mukesh M, Fischer Ute, Fulcher David A, Gallo Silvanna, Gauthier Amelie, Gennery Andrew R, Gonçalo Marques José, Gottrand Frédéric, Grimbacher Bodo, Grunebaum Eyal, Haapaniemi Emma, Hämäläinen Sari, Heiskanen Kaarina, Heiskanen-Kosma Tarja, Hoffman Hal M, Gonzalez-Granado Luis Ignacio, Guerrerio Anthony L, Kainulainen Leena, Kumar Ashish, Lawrence Monica G, Levin Carina, Martelius Timi, Neth Olaf, Olbrich Peter, Palma Alejandro, Patel Niraj C, Pozos Tamara, Preece Kahn, Lugo Reyes Saúl Oswaldo, Russell Mark A, Schejter Yael, Seroogy Christine, Sinclair Jan, Skevofilax Effie, Suan Daniel, Suegeorgz Daniel, Szabolcs Paul, Velasco Helena, Warnatz Klaus, Walkovich Kelly, Worth Austen; STAT3 GOF Working Group members, Seppänen Mikko RJ, Torgerson Troy R, Sogkas Georgios, Ehl Stephan, Tangye Stuart G, Cooper Megan A, Milner Joshua D, Forbes Satter Lisa R
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation (2022)

Immunity
Masle-Farquhar E, Jackson KJL, Peters TJ, Al-Eryani G, Singh M, Payne KJ, Rao G, Avery DT, Apps G, Kingham J, Jara CJ, Skvortsova K, Swarbrick A, Ma CS, Suan D, Uzel G, Chua I, Leiding JW, Heiskanen K, Preece K, Kainulainen L, O'Sullivan M, Cooper MA, Seppänen MRJ, Mustjoki S, Brothers S, Vogel TP, Brink R, Tangye SG, Reed JH, Goodnow CC
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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