Leena Kainulainen profile picture
Leena
Kainulainen
Docent, Paediatrics and Adolescent Medicine

Areas of expertise

paediatrics
immunodeficiency
paediatric infectious diseases
respiratory infections
rhinovirus

Biography

Docent Leena Kainulainen graduated from medical school in 1995(University of Turku) and defended her PhD theses on CVID in 2000. She received specialist licence in paediatrics in 2005 and in pediatric infectious diseases 2013 and was appointed as a docent in paediatrics in 2013 (University of Turku). She is currently working as Head of the Division of Pediatric Care in Turku University Hospital and as an immunology consultant at Department of Pediatrics and Medicine at Turku University Hospital. She participates in neonatal screening for severe immunodeficiencies.


Teaching

Docent Kainulainen has been working as a clinical lecturer in pediatrics 2004 and 2006. Currently she teaches regularly medical students and paediatric residents as a part of her clinical duties.


Research

Docent Kainulainen´s research is  focused on primary immunodeficiency. Her current research interests comprise rhinovirus infections in primary hypogammaglobulinemia patients. Clinical trial on the treatment of rhinovirus infection with pegylated interferon alfa in CVID patients is ongoing. Research project on innate immunity in autoimmune patients is ongoing. In addition, she participates in research project aiming at  evaluating immunological status in pediatric patients with neonatal cardiac surgery.


Publications

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Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child (2021)

Nature Medicine
Ogishi Masato, Yang Rui, Aytekin Caner, Langlais David, Bourgey Mathieu, Khan Taushif, Al Ali Fatima, Rahman Mahbuba, Delmonte Ottavia M., Chrabieh Maya, Zhang Peng, Gruber Conor, Pelham Simon J., Spaan András N., Rosain Jérémie, Lei Wei-Te, Drutman Scott, Hellmann Matthew D., Callahan Margaret K., Adamow Matthew, Wong Phillip, Wolchok Jedd D., Rao Geetha, Ma Cindy S., Nakajima Yuka, Yaguchi Tomonori, Chamoto Kenji, Williams Samuel C., Emile Jean-Francois, Rozenberg Flore, Glickman Michael S., Rapaport Franck, Kerner Gaspard, Allington Garrett, Tezcan Ilhan, Cagdas Deniz, Hosnut Ferda O., Dogu Figen, Ikinciogullari Aydan, Rao V. Koneti, Kainulainen Leena, Béziat Vivien, Bustamante Jacinta, Vilarinho Silvia, Lifton Richard P., Boisson Bertrand, Abel Laurent, Bogunovic Dusan, Marr Nico, Notarangelo Luigi D., Tangye Stuart G., Honjo Tasuku, Gros Philippe, Boisson-Dupuis Stéphanie, Casanova Jean-Laurent
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Clinical, functional and genetic characterization of 16 patients suffering from chronic granulomatous disease variants - identification of 11 novel mutations in CYBB (2021)

Clinical and Experimental Immunology
Mollin M, Beaumel S, Vigne B, Brault J, Roux-Buisson N, Rendu J, Barlogis V, Catho G, Dumeril C, Fouyssac F, Monnier D, Gandemer V, Revest M, Brion JP, Bost-Bru C, Jeziorski E, Eitenschenck L, Jarrasse C, Haus SD, Houachee-Chardin M, Hancart M, Michel G, Bertrand Y, Plantaz D, Kelecic J, Traberg R, Kainulainen L, Faure J, Fieschi F, Stasia MJ
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Multibatch Cytometry Data Integration for Optimal Immunophenotyping (2021)

Journal of Immunology
Ogishi Masato, Yang Rui, Gruber Conor, Zhang Peng, Pelham Simon J, Spaan András N, Rosain Jérémie, Chbihi Marwa, Han Ji Eun, Rao V Koneti, Kainulainen Leena, Bustamante Jacinta, Boisson Bertrand, Bogunovic Dusan, Boisson-Dupuis Stéphanie, Casanova Jean-Laurent
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Suomi on synnynnäisten immuunivajeiden maa (2018)

Duodecim
Taskinen M, Kainulainen L, Heiskanen K, Kainulainen L, Renko M, Heiskanen-Kosma T, Tapiainen T, Vettenranta K, Lukkarinen H, Heikinheimo M, Seppänen M
(Artikkeli ammattilehdessä tai kirjoitus ammatillisessa blogissa (D1))