Johanna
Lempainen
Docent, Department of Clinical Medicine
Clinical Lecturer, Institute of Biomedicine
Clinical lecturer
Contact
Areas of expertise
pediatrics
pathogenesis of type 1 diabetes
pediatric infections
pediatric immunology
Biography
Docent Johanna Lempainen
graduated from medical school in 2004 (University of Turku) and defended her
PhD theses on pathogenesis of type 1 diabetes in 2009. She received specialist
licence in paediatrics in 2015 and was appointed as a docent of experimental
paediatrics in 2018 (University of Turku). She is currently working as clinical
lecturer at the department of pediatrics at University of Turku and as
specialist at the Unit for Rare Diseases, Turku University Hospital. She
participates in neonatal screening for severe immunodeficiencies and in
laboratory diagnostics of immunodeficiencies. Training for subspecialty in
pediatric infections and immunodeficiencies is ongoing.
Teaching
Docent Lempainen works
as clinical lecturer in pediatrics (part-time) since January 2017.
Research
Docent Lempainen’s
thesis in 2009 focused on the pathogenesis of type 1 diabetes. Since then her
research work has further focused on the heterogeneity of type 1 diabetes
pathogenesis. In 2011 she worked as visiting researcher in the
BabyDiab-diabetes study group in Munich,
Germany. Her current research interests comprise the etiology of beta-cell
autoimmunity in respect of immunological, genetic and epigenetic factors and
disturbances in early microbial contacts and are a part of the prospective
Diabetes Prediction and Prevention (DIPP) study. In addition, she participates
in research projects aiming at early detection of bacterial and viral
infections in infants and children in order to avoid unnecessary antibiotic
exposure. Since January 2020 docent Lempainen is the principal investigator of the Immunogenetics laboratory and PI and member of steering committee in the DIPP study at the University of Turku.
Publications
Neonatal and early infancy antibiotic exposure is associated with childhood atopic dermatitis, wheeze and asthma (2024)
European Journal of Pediatrics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
The effect of early life cytomegalovirus infection on the immune profile of children (2024)
Clinical Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Neutralizing antibodies after the third COVID-19 vaccination in healthcare workers with or without breakthrough infection (2024)
Communications medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Increased Frequency of the HLA-DRB1*04:04-DQA1*03-DQB1*03:02 Haplotype Among HLA-DQB1*06:02-Positive Children With Type 1 Diabetes (2024)
Diabetes
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Household Transmission and Clinical Features of SARS-CoV-2-Positive and -Negative Respiratory Tract Infections (2024)
Journal of Infectious Diseases
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
The effect of type 1 diabetes protection and susceptibility associated HLA class II genotypes on DNA methylation in immune cells (2024)
HLA
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Temporal Alterations in CD8+ T Cells During the Progression from Stage 1 to Stage 3 Type 1 Diabetes (2024)
Diabetes
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies (2024)
Nature Communications
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
SARS-CoV-2 and type 1 diabetes in children in Finland: an observational study (2023)
Lancet Diabetes and Endocrinology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
DNA methylation differences within INS, PTPN22 and IL2RA promoters in lymphocyte subsets in children with type 1 diabetes and controls (2023)
Autoimmunity
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))