Tiina
Laitala
Docent, Institute of Biomedicine
University Lecturer, Institute of Biomedicine
Links
Areas of expertise
mTBI
microRNA
imaging
concussion
neuroanatomy
visuomotor research
tissue trauma healing
skeletal biology
sports trauma
Teaching
- Neuroanatomy
- Human gross anatomy
- Histology
- Cell biology
- Sports trauma
Research
Our research focuses on the mechanisms involved in short regulatory RNA physiology. These molecules (siRNAs, shRNAs, microRNAs) modulate gene expression, thus affecting not only differentiation and developmental maturation of cells and organ systems, but also tissue healing after trauma.
Publications
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption (2001)
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))Inhibition of intravacuolar acidification by antisense RNA decreases osteoclast differentiation and bone resorption in vitro (1999)
Journal of Cell Science
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Decreased bone resorption, osteoclast differentiation, and expression of vacuolar H+-ATPase in antisense DNA-treated mouse metacarpal and calvaria cultures ex vivo (1999)
Antisense and Nucleic Acid Drug Development
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Carbonic anhydrase II plays a major role in osteoclast differentiation and bone resorption by effecting the steady state intracellular pH and Ca2+ (1998)
Experimental Cell Research
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))