Olli Tenovuo profile picture
Olli
Tenovuo
Docent, Faculty of Medicine
MD, PhD, Prof. of Neurotraumatology
Pathophysiology, diagnostics, treatment, and prognosis of traumatic brain injury

Contact

Links

CV – Olli Tenovuo.pdf
Publications.pdf
ORCID

Areas of expertise

traumatic brain injury
rehabilitation
biomarkers
imaging

Biography

I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.

Teaching

Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.

Research

The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.

Publications

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Rehabilitation and outcomes after complicated vs uncomplicated mild TBI: results from the CENTER-TBI study (2022)

BMC Health Services Research
Howe E.I., Zeldovich M., Andelic N., von Steinbuechel N., Fure S.C.R., Borgen I.M.H., Forslund M.V., Hellstrøm T., Søberg H.L., Sveen U., Rasmussen M., Kleffelgaard I., Tverdal C., Helseth E., Løvstad M., Lu J., Arango-Lasprilla J.C., Tenovuo O., Azouvi P., Dawes H., Roe C; & CENTER-TBI participants and investigators
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Serum metabolome associated with severity of acute traumatic brain injury (2022)

Nature Communications
Thomas Ilias, Dickens Alex M, Posti Jussi P, Czeiter Endre, Duberg Daniel, Sinioja Tim, Kråkström Matilda, Helmrich Isabel RA Retel, Wang Kevin KW, Maas Andrew IR, Steyerberg Ewout W, Menon David K, Tenovuo Olli, Hyötyläinen Tuulia, Büki András, Orešič Matej; Group author: CENTER-TBI Participants and Investigators
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Potential of heart fatty-acid binding protein, neurofilament light, interleukin-10 and S100 calcium-binding protein B in the acute diagnostics and severity assessment of traumatic brain injury (2022)

Emergency Medicine Journal
Koivikko Pia, Posti Jussi P., Mohammadian Mehrbod, Lagerstedt Linnea, Azurmendi Leire, Hossain Iftakher, Katila Ari J., Menon David, Newcombe Virginia F. J., Hutchinson Peter John, Maanpaa Henna-Riikka, Tallus Jussi, Zetterberg Henrik, Blennow Kaj, Tenovuo Olli, Sanchez Jean-Charles, Takala Riikka S. K.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Post-acute blood biomarkers and disease progression in traumatic brain injury (2022)

Brain
Newcombe Virginia FJ, Ashton Nicholas J, Posti Jussi P, Glocker Ben, Manktelow Anne, Chatfield Doris A, Winzeck Stefan, Needham Edward, Correia Marta M, Williams Guy B, Simrén Joel, Takala Riikka SK, Katila Ari J, Maanpää Henna Riikka, Tallus Jussi, Frantzén Janek, Blennow Kaj, Tenovuo Olli, Zetterberg Henrik, Menon David K
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Structural Brain Connectivity Correlates with Outcome in Mild Traumatic Brain Injury (2022)

Journal of Neurotrauma
Roine Timo, Mohammadian Mehrbod, Hirvonen Jussi, Kurki Timo, Posti Jussi P, Takala Riikka SK, Newcombe Virginia F, Tallus Jussi, Katila Ari J, Maanpää Henna-Riikka, Frantzen Janek, Menon David, Tenovuo Olli
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Traumatic brain injury: progress and challenges in prevention, clinical care, and research (2022)

Lancet Neurology
Maas AIR, Menon DK, Manley GT, Abrams M, Akerlund C, Andelic N, Aries M, Bashford T, Bell MJ, Bodien YG, Brett BL, Buki A, Chesnut RM, Citerio G, Clark D, Clasby B, Cooper DJ, Czeiter E, Czosnyka M, Dams-O'Connor K, De Keyser V, Diaz-Arrastia R, Ercole A, van Essen TA, Falvey E, Ferguson AR, Figaji A, Fitzgerald M, Foreman B, Gantner D, Gao GY, Giacino J, Gravesteijn B, Guiza F, Gupta D, Gurnell M, Haagsma JA, Hammond FM, Hawryluk G, Hutchinson P, van der Jagt M, Jain S, Jain S, Jiang JY, Kent H, Kolias A, Kompanje EJO, Lecky F, Lingsma HF, Maegele M, Majdan M, Markowitz A, McCrea M, Meyfroidt G, Mikoli A, Mondello S, Mukherjee P, Nelson D, Nelson LD, Newcombe V, Okonkwo D, Oresic M, Peul W, Pisica D, Polinder S, Ponsford J, Puybasset L, Raj R, Robba C, Roe C, Rosand J, Schueler P, Sharp DJ, Smielewski P, Stein MB, von Steinbuchel N, Stewart W, Steyerberg EW, Stocchetti N, Temkin N, Tenovuo O, Theadom A, Thomas I, Espin AT, Turgeon AF, Unterberg A, Van Praag D, van Veen E, Verheyden J, Vande Vyvere T, Wang KKW, Wiegers EJA, Williams WH, Wilson L, Wisniewski SR, Younsi A, Yue JK, Yuh EL, Zeiler FA, Zeldovich M, Zemek R
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Unmet Rehabilitation Needs after Traumatic Brain Injury across Europe: Results from the CENTER-TBI Study (2021)

Journal of Clinical Medicine
Andelic Nada, Roe Cecilie, Tenovuo Olli, Azouvi Philippe, Dawes Helen, Majdan Marek, Ranta Jukka, Howe Emilie I, Wiegers Eveline JA, Tverdal Cathrine, Borgen Ida, Forslund Marit V, Kleffelgaard Ingerid, Dahl Hilde M, Jacob Louis, Cogne Mélanie, Lu Juan, von Steinbuechel Nicole, Zeldovich Marina; CENTER-TBI Participants
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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