Olli Tenovuo profile picture
Olli
Tenovuo
Docent, Faculty of Medicine
MD, PhD, Prof. of Neurotraumatology
Pathophysiology, diagnostics, treatment, and prognosis of traumatic brain injury

Contact

Areas of expertise

traumatic brain injury
rehabilitation
biomarkers
imaging

Biography

I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.

Teaching

Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.

Research

The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.

Publications

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Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study (2019)

Lancet Neurology
Steyerberg EW, Wiegers E, Sewalt C, Buki A, Citerio G, De Keyser V, Ercole A, Kunzmann K, Lanyon L, Lecky F, Lingsma H, Manley G, Nelson D, Peul W, Stocchetti N, von Steinbuchel N, Vande Vyvere T, Verheyden J, Wilson L, Maas AIR, Menon DK; and the CENTER-TBI Participants and Investigators
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Correlation of blood biomarkers and biomarker panels with traumatic findings on computed tomography after traumatic brain injury (2019)

Journal of Neurotrauma
Posti JP, Takala RS, Lagerstedt L, Dickens AM, Hossain I, Mohammadian M, Ala-Seppälä HM, Frantzén J, Van Gils M, Hutchinson PJ, Katila AJ, Maanpää HR, Menon D, Newcombe V, Tallus J, Hrusovsky K, Wilson D, Gill J, Sanchez JC, Tenovuo O, Zetterberg H, Blennow K.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Serum Metabolites Associated with Computed Tomography Findings after Traumatic Brain Injury (2018)

Journal of Neurotrauma
Dickens AM, Posti JP, Takala RSK, Ala-Seppala H, Mattila I, Coles JP, Frantzen J, Hutchinson PJ, Katila AJ, Kyllonen A, Maanpaa HR, Newcombe V, Outtrim J, Tallus J, Carpenter KLH, Menon DK, Hyotylainen T, Tenovuo O, Oresic M, Oresic M
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Variation in general supportive and preventive intensive care management of traumatic brain injury: a survey in 66 neurotrauma centers in participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study (2018)

Critical Care
Hujiben JA, Volovici V, Cnossen MC, Haitsma IK, Stocchetti N, Maas AIR, Menon DK, Ercole A, Citerio G, Nelson D, Polinder S, Steyerberg EW, Lingsma HF, van der Jagt M; CENTER-TBI investigators and participants
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))