Olli Raitakari profile picture
Olli
Raitakari
Professor, Cardiovascular Medicine (CAPC)
InFLAMES Flagship
MD/PhD

Contact

+358 29 450 2304
Kiinamyllynkatu 10
20520
Turku

Areas of expertise

cardiovascular and metabolic diseases
risk factors
vascular epidemiology
genetic epidemiology
epidemiology
dietary intervention
cohort studies
follow-up studies

Biography

EDUCATION AND DEGREES
 
2001   Docent in Clinical Physiology
1997-1999  Postdoc training, Royal Prince Alfred Hospital, Sydney, Australia
1997   Docent in Epidemiology
1996   Specialist in Clinical Physiology 
1995   Doctorate, PhD
1989   Licentiate in Medicine, MD

CURRENT POSITIONS

2017-                 Professor in Cardiovascular Medicine, Director of the Research Centre of Applied and 
                          Preventive Cardiovascular Medicine, University of Turku, Finland                         

 

PAST POSITIONS

2012-2016                          Academy Professor, University of Turku

2007-2016                          Professor in Cardiovascular Medicine (part time), University of Turku

2007-2008                          Senior Scientist Grant, Academy of Finland

2004-2016                          Chief Physician, Department of Clinical Physiology and Nuclear Medicine, Turku
                                           University Hospital (leave of absence 2012-2016)

2002-2004                          Consultant in Clinical Physiology and Nuclear Medicine, Turku University Hospital

2002 (1 mo)                        Head of Nuclear Medicine Department, Turku University Hospital

2000-2003 (3 mo)               Head of Clinical Physiology Department, Turku University Hospital

2000-2005                          Senior Fellow Post, Academy of Finland

1998-2000                          Postdoctoral Research Post, Academy of Finland

1996-1997                          Consultant in Clinical Physiology, Turku University Hospital

1991-1996                          Positions as Resident in Clinical Chemistry, Nuclear Medicine, and Clinical 
                                           Physiology, Turku University Hospital

1988-1990                          Positions as General Practioner and Resident in Internal Medicine or Surgery


Research

Evidence suggest that many non-communicable disease outcomes have roots in childhood and may even stem of adverse ancestral exposures. Improved knowledge how various ancestral and early-life exposures lead to adult disease outcomes is essential in developing better preventive practices and policies that lead to improved public health. My mission has been to contribute to this knowledge-base by working in epidemiologic cohort studies with follow-up from childhood to adulthood. I am the Principal Investigator of the Cardiovascular Risk in Young Finns Study (YFS), the largest study in Europe with a follow-up of cardiovascular risk factors from childhood to adulthood. I am also the Director of the STRIP Study, which is a leading long-term pediatric dietary intervention study testing the hypothesis that modifying the fat quality diet will have beneficial effects on cardiovascular risk early in life. During the past years, I have organized several field studies in these cohorts, and introduced novel technologies, such as imaging studies, genetic epidemiology methods and metabolomics approaches in these unique population resources. Our research has contributed to the understanding of pre-clinical development of atherosclerosis in children and young adults, including the effects of diet, life-style, metabolic risk factors, psychological traits and psychosocial factors, inflammation, hormones and genetic markers. For example, by applying non-invasive imaging methods in the Young Finns Study, we have demonstrated that exposure to adverse lipids, elevated blood pressure and obesity in childhood is related to atherosclerosis development in adulthood (JAMA 2003). Subsequent work stemmed from this initial observation has led to numerous original publications that have shown in detail how exposure to a large range of aetiogenic factors early in life contribute to the development of cardio-metabolic outcomes in adulthood. For example, by pooling international i3C Consortium data, we have demonstrated that overweight or obese children who became non-obese by adulthood had similar risks of many cardio-metabolic adult outcomes as individuals who were never obese (NEJM 2011). Thus, the results of our studies have clearly demonstrated that individual’s exposure to various stressors in early life is contributing to his/her adult phenotype and disease risk. The results have had significant impact on preventive practices. As a concrete demonstration of the international recognition and impact of my team’s work, many of our studies are widely cited in all updated paediatric guidelines on cardiovascular prevention both in Europe and in US.

Publications

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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (2017)

Nature Genetics
Warren HR, Evangelou E, Cabrera CP, Gao H, Ren MX, Mifsud B, Ntalla I, Surendran P, Liu CY, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N, Marten J, Karaman I, Lepe MPS, O'Reilly PF, Knight J, Snieder H, Kato N, He J, Tai ES, Said MA, Porteous D, Alver M, Poulter N, Farrall M, Gansevoort RT, Padmanabhan S, Magi R, Stanton A, Connell J, Bakker SJL, Metspalu A, Shields DC, Thom S, Brown M, Sever P, Esko T, Hayward C, van der Harst P, Saleheen D, Chowdhury R, Chambers JC, Chasman DI, Chakravarti A, Newton-Cheh C, Lindgren CM, Levy D, Kooner JS, Keavney B, Tomaszewski M, Samani NJ, Howson JMM, Tobin MD, Munroe PB, Ehret GB, Wain LV, Barnes MR, Tzoulaki J, Caulfield MJ, Elliott P, Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly P, Cabrera CP, Warren HR, Rose LM, Verwoert GC, Hottenga JJ, Strawbridge RJ, Esko T, Arking DE, Hwang SJ, Guo XQ, Kutalik Z, Trompet S, Shrine N, Teumer A, Ried JS, Bis JC, Smith AV, Amin N, Nolte IM, Lyytikainen LP, Mahajan A, Wareham NJ, Hofer E, Joshi PK, Kristiansson K, Traglia M, Havulinna AS, Goel A, Nalls MA, Sober S, Vuckovic D, Luan JA, Del Greco F, Ayers KL, Marrugat J, Ruggiero D, Lopez LM, Niiranen T, Enroth S, Jackson AU, Nelson CP, Huffman JE, Zhang WH, Marten J, Gandin I, Harris SE, Zemonik T, Lu YC, Evangelou E, Shah N, de Borst MH, Mangino M, Prins BP, Campbell A, Li-Gao RF, Chauhan G, Oldmeadow C, Abecasis G, Abedi M, Barbieri CM, Barnes MR, Batini C, Blake T, Boehnke M, Bottinger EP, Braund PS, Brown M, Brumat M, Campbell H, Chambers JC, Cocca M, Collins F, Connell J, Cordell HJ, Damman JJ, Davies G, de Geus EJ, de Mutsert R, Deelen J, Demirkale Y, Doney ASF, Dorr M, Farrall M, Ferreira T, Franberg M, Gao H, Giedraitis V, Gieger C, Giulianini F, Gow AJ, Hamsten A, Harris TB, Hofman A, Holliday EG, Jarvelin MR, Johansson A, Johnson AD, Jousilahti P, Jula A, Kahonen M, Kathiresan S, Khaw KT, Kolcic I, Koskinen S, Langenberg C, Larson M, Launer LJ, Lehne B, Liewald DCM, Lin L, Lind L, Mach F, Mamasoula C, Menni C, Mifsud B, Milaneschi Y, Morgan A, Morris AD, Morrison AC, Munson PJ, Nandakumar P, Nguyen QT, Nutile T, Oldehinkel AJ, Oostra BA, Org E, Padmanabhan S, Palotie A, Pare G, Pattie A, Penninx BWJH, Poulter N, Pramstaller PP, Raitakari OT, Ren MX, Rice K, Ridker PM, Riese H, Ripatti S, Robino A, Rotter JI, Rudan I, Saba Y, Saint Pierre A, Sala CF, Sarin AP, Schmidt R, Scott R, Seelen MA, Shields DC, Siscovick D, Sorice R, Stanton A, Stott DJ, Sundstrom J, Swertz M, Taylor KD, Thom S, Tzoulaki I, Tzourio C, Uitterlinden AG, Volker U, Vollenweider P, Wild S, Willemsen G, Wright AF, Yao J, Theriault S, Conen D, John A, Sever P, Debette S, Mook-Kanamori DO, Zeggini E, Spector TD, van der Harst P, Palmer CNA, Vergnaud AC, Loos RJF, Polasek O, Starr JM, Girotto G, Hayward C, Kooner JS, Lindgren CM, Vitart V, Samani NJ, Tuomilehto J, Gyllensten U, Knekt P, Deary IJ, Ciullo M, Elosua R, Keavney BD, Hicks AA, Scott RA, Gasparini P, Laan M, Liu YM, Watkins H, Hartman CA, Salomaa V, Toniolo D, Perola M, Wilson JF, Schmidt H, Zhao JH, Lehtimaki T, van Duijn CM, Gudnason V, Psaty BM, Peters A, Rettig R, James A, Jukema JW, Strachan DP, Palmas W, Metspalu A, Ingelsson E, Boomsma DI, Franco OH, Bochud M, Newton-Cheh C, Munroe PB, Elliott P, Chasman DI, Chakravarti A, Knight J, Morris AP, Levy D, Tobin MD, Snieder H, Caulfield MJ, Ehret GB, Ehret GB
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women (2017)

Lancet
Stringhini S., Carmeli C., Jokela M., Avendaño M., Muennig P., Guida F., Ricceri F., d'Errico A., Barros H., Bochud M., Chadeau-Hyam M., Clavel-Chapelon F., Costa G., Delpierre C., Fraga S., Goldberg M., Giles G., Krogh V., Kelly-Irving M., Layte R., Lasserre A., Marmot M., Preisig M., Shipley M., Vollenweider P., Zins M., Kawachi I., Steptoe A., Mackenbach J., Vineis P., Kivimäki M. ; for the LIFEPATH consortium
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Childhood age and associations between childhood metabolic syndrome and adult risk for metabolic syndrome, type 2 diabetes mellitus and carotid intima media thickness: The international childhood cardiovascular cohort consortium (2017)

Journal of the American Heart Association
Juha Koskinen, Costan G. Magnussen, Alan Sinaiko, Jessica Woo, Elaine Urbina, David R. Jacobs, Julia Steinberger, Ronald Prineas, Matthew A. Sabin, Trudy Burns, Gerald Berenson, Lydia Bazzano, Alison Venn, Jorma S.A. Viikari, Nina Hutri‐Kähönen, Olli Raitakari, Terence Dwyer, Markus Juonala
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Association of Socioeconomic Status in Childhood With Left Ventricular Structure and Diastolic Function in Adulthood The Cardiovascular Risk in Young Finns Study (2017)

JAMA Pediatrics
Laitinen TT, Puolakka E, Ruohonen S, Magnussen CG, Smith KJ, Viikari JSA, Heinonen OJ, Kartiosuo N, Hutri-Kahonen N, Kahonen M, Jokinen E, Laitinen TP, Tossavainen P, Pulkki-Raback L, Elovainio M, Raitakari OT, Pahkala K, Juonala M
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts (2017)

PLoS ONE
Mozaffarian D, Dashti HS, Wojczynski MK, Chu AY, Nettleton JA, Männistö S, Kristiansson K, Reedik M, Lahti J, Houston DK, Cornelis MC, van Rooij FJA, Dimitriou M, Kanoni S, Mikkilä V, Steffen LM, de Oliveira Otto MC, Qi L, Psaty B, Djousse L, Rotter JI, Harald K, Perola M, Rissanen H, Jula A, Krista F, Mihailov E, Feitosa MF, Ngwa JS, Xue L, Jacques PF, Perälä MM, Palotie A, Liu Y, Nalls NA, Ferrucci L, Hernandez D, Manichaikul A, Tsai MY, Kiefte-de Jong JC, Hofman A, Uitterlinden AG, Rallidis L, Ridker PM, Rose LM, Buring JE, Lehtimäki T, Kähönen M, Viikari J, Lemaitre R, Salomaa V, Knekt P, Metspalu A, Borecki IB, Cupples LA, Eriksson JG, Kritchevsky SB, Bandinelli S, Siscovick D, Franco OH, Deloukas P, Dedoussis G, Chasman DI, Raitakari O, Tanaka T
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Positive Psychosocial Factors in Childhood Predicting Lower Risk for Adult Type 2 Diabetes: The Cardiovascular Risk in Young Finns Study, 1980-2012 (2017)

American Journal of Preventive Medicine
Pulkki-Råback L, Elovainio M, Hakulinen C, Lipsanen J, Kubzansky LD, Hintsanen M, Savelieva K, Serlachius A, Magnussen CG, Sabin MA, Burgner DP, Lehtimäki T, Jokinen E, Rönnemaa T, Mikkilä V, Jula A, Hutri-Kähönen N, Viikari J, Keltikangas-Jarvinen L, Raitakari O, Juonala M
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits (2017)

Nature Communications
Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski J, Hadley D, Ngwa JS, Ahluwalia TS, Chu AY, Heard-Costa NL, Lim E, Perez J, Eicher JD, Kutalik Z, Xue L, Mahajan A, Renstrom F, Wu J, Qi QB, Ahmad S, Alfred T, Amin N, Bielak LF, Bonnefond A, Bragg J, Cadby G, Chittani M, Coggeshall S, Corre T, Direk N, Eriksson J, Fischer K, Gorski M, Harder MN, Horikoshi M, Huang T, Huffman JE, Jackson AU, Justesen JM, Kanoni S, Kinnunen L, Kleber ME, Komulainen P, Kumari M, Lim U, Luan J, Lyytikainen LP, Mangino M, Manichaikul A, Marten J, Middelberg RPS, Mueller-Nurasyid M, Navarro P, Perusse L, Pervjakova N, Sarti C, Smith AV, Smith JA, Stancakova A, Strawbridge RJ, Stringham HM, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van der Most PJ, Van Vliet-Ostaptchouk JV, Vedantam SL, Verweij N, Vink JM, Vitart V, Wu Y, Yengo L, Zhang WH, Zhao JH, Zimmermann ME, Zubair N, Abecasis GR, Adair LS, Afaq S, Afzal U, Bakker SJL, Bartz TM, Beilby J, Bergman RN, Bergmann S, Biffar R, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Braga D, Buckley BM, Buyske S, Campbell H, Chambers JC, Collins FS, Curran JE, de Borst GJ, de Craen AJM, de Geus EJC, Dedoussis G, Delgado GE, den Ruijter HM, Eiriksdottir G, Eriksson AL, Esko T, Faul JD, Ford I, Forrester T, Gertow K, Gigante B, Glorioso N, Gong J, Grallert H, Grammer TB, Grarup N, Haitjema S, Hallmans G, Hamsten A, Hansen T, Harris TB, Hartman CA, Hassinen M, Hastie ND, Heath AC, Hernandez D, Hindorff L, Hocking LJ, Hollensted M, Holmen OL, Homuth G, Hottenga JJ, Huang J, Hung J, Hutri-Kahonen N, Ingelsson E, James AL, Jansson JO, Jarvelin MR, Jhun MA, Jorgensen ME, Juonala M, Kahonen M, Karlsson M, Koistinen HA, Kolcic I, Kolovou G, Kooperberg C, Kramer BK, Kuusisto J, Kvaloy K, Lakka TA, Langenberg C, Launer LJ, Leander K, Lee NR, Lind L, Lindgren CM, Linneberg A, Lobbens S, Loh M, Lorentzon M, Luben R, Lubke G, Ludolph-Donislawski A, Lupoli S, Madden PAF, Mannikko R, Marques-Vidal P, Martin NG, McKenzie CA, McKnight B, Mellstrom D, Menni C, Montgomery GW, Musk AW, Narisu N, Nauck M, Nolte IM, Oldehinkel AJ, Olden M, Ong KK, Padmanabhan S, Peyser PA, Pisinger C, Porteous DJ, Raitakari OT, Rankinen T, Rao DC, Rasmussen-Torvik LJ, Rawal R, Rice T, Ridker PM, Rose LM, Bien SA, Rudan I, Sanna S, Sarzynski MA, Sattar N, Savonen K, Schlessinger D, Scholtens S, Schurmann C, Scott RA, Sennblad B, Siemelink MA, Silbernagel G, Slagboom PE, Snieder H, Staessen JA, Stott DJ, Swertz MA, Swift AJ, Taylor KD, Tayo BO, Thorand B, Thuillier D, Tuomilehto J, Uitterlinden AG, Vandenput L, Vohl MC, Volzke H, Vonk JM, Waeber G, Waldenberger M, Westendorp RGJ, Wild S, Willemsen G, Wolffenbuttel BHR, Wong A, Wright AF, Zhao W, Zillikens MC, Baldassarre D, Balkau B, Bandinelli S, Boger CA, Boomsma DI, Bouchard C, Bruinenberg M, Chasman DI, Chen YDI, Chines PS, Cooper RS, Cucca F, Cusi D, de Faire U, Ferrucci L, Franks PW, Froguel P, Gordon-Larsen P, Grabe HJ, Gudnason V, Haiman CA, Hayward C, Hveem K, Johnson AD, Jukema W, Kardia SLR, Kivimaki M, Kooner JS, Kuh D, Laakso M, Lehtimaki T, Le Marchand L, Marz W, McCarthy MI, Metspalu A, Morris AP, Ohlsson C, Palmer LJ, Pasterkamp G, Pedersen O, Peters A, Peters U, Polasek O, Psaty BM, Qi L, Rauramaa R, Smith BH, Sorensen TIA, Strauch K, Tiemeier H, Tremoli E, Van der Harst P, Vestergaard H, Vollenweider P, Wareham NJ, Weir DR, Whitfield JB, Wilson JF, Tyrrell J, Frayling TM, Barroso I, Boehnke M, Deloukas P, Fox CS, Hirschhorn JN, Hunter DJ, Spector TD, Strachan DP, van Duijn CM, Heid IM, Mohlke KL, Marchini J, Loos RJF, Kilpelainen TO, Liu CT, Borecki IB, North KE, Cupples LA, Hunter DJ, Hirschhorn JN, Strachan DP, Spector TD, Heid IM, van Duijn CM, Marchini J, Mohlke KL, Kilpelainen TO, Loos RJF, Borecki IB, Liu CT, Cupples LA, North KE
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))