Olli Raitakari profile picture
Olli
Raitakari
Professor, Cardiovascular Medicine (CAPC)
InFLAMES Flagship
MD/PhD

Contact

+358 29 450 2304
Kiinamyllynkatu 10
20520
Turku

Areas of expertise

cardiovascular and metabolic diseases
risk factors
vascular epidemiology
genetic epidemiology
epidemiology
dietary intervention
cohort studies
follow-up studies

Biography

EDUCATION AND DEGREES
 
2001   Docent in Clinical Physiology
1997-1999  Postdoc training, Royal Prince Alfred Hospital, Sydney, Australia
1997   Docent in Epidemiology
1996   Specialist in Clinical Physiology 
1995   Doctorate, PhD
1989   Licentiate in Medicine, MD

CURRENT POSITIONS

2017-                 Professor in Cardiovascular Medicine, Director of the Research Centre of Applied and 
                          Preventive Cardiovascular Medicine, University of Turku, Finland                         

 

PAST POSITIONS

2012-2016                          Academy Professor, University of Turku

2007-2016                          Professor in Cardiovascular Medicine (part time), University of Turku

2007-2008                          Senior Scientist Grant, Academy of Finland

2004-2016                          Chief Physician, Department of Clinical Physiology and Nuclear Medicine, Turku
                                           University Hospital (leave of absence 2012-2016)

2002-2004                          Consultant in Clinical Physiology and Nuclear Medicine, Turku University Hospital

2002 (1 mo)                        Head of Nuclear Medicine Department, Turku University Hospital

2000-2003 (3 mo)               Head of Clinical Physiology Department, Turku University Hospital

2000-2005                          Senior Fellow Post, Academy of Finland

1998-2000                          Postdoctoral Research Post, Academy of Finland

1996-1997                          Consultant in Clinical Physiology, Turku University Hospital

1991-1996                          Positions as Resident in Clinical Chemistry, Nuclear Medicine, and Clinical 
                                           Physiology, Turku University Hospital

1988-1990                          Positions as General Practioner and Resident in Internal Medicine or Surgery


Research

Evidence suggest that many non-communicable disease outcomes have roots in childhood and may even stem of adverse ancestral exposures. Improved knowledge how various ancestral and early-life exposures lead to adult disease outcomes is essential in developing better preventive practices and policies that lead to improved public health. My mission has been to contribute to this knowledge-base by working in epidemiologic cohort studies with follow-up from childhood to adulthood. I am the Principal Investigator of the Cardiovascular Risk in Young Finns Study (YFS), the largest study in Europe with a follow-up of cardiovascular risk factors from childhood to adulthood. I am also the Director of the STRIP Study, which is a leading long-term pediatric dietary intervention study testing the hypothesis that modifying the fat quality diet will have beneficial effects on cardiovascular risk early in life. During the past years, I have organized several field studies in these cohorts, and introduced novel technologies, such as imaging studies, genetic epidemiology methods and metabolomics approaches in these unique population resources. Our research has contributed to the understanding of pre-clinical development of atherosclerosis in children and young adults, including the effects of diet, life-style, metabolic risk factors, psychological traits and psychosocial factors, inflammation, hormones and genetic markers. For example, by applying non-invasive imaging methods in the Young Finns Study, we have demonstrated that exposure to adverse lipids, elevated blood pressure and obesity in childhood is related to atherosclerosis development in adulthood (JAMA 2003). Subsequent work stemmed from this initial observation has led to numerous original publications that have shown in detail how exposure to a large range of aetiogenic factors early in life contribute to the development of cardio-metabolic outcomes in adulthood. For example, by pooling international i3C Consortium data, we have demonstrated that overweight or obese children who became non-obese by adulthood had similar risks of many cardio-metabolic adult outcomes as individuals who were never obese (NEJM 2011). Thus, the results of our studies have clearly demonstrated that individual’s exposure to various stressors in early life is contributing to his/her adult phenotype and disease risk. The results have had significant impact on preventive practices. As a concrete demonstration of the international recognition and impact of my team’s work, many of our studies are widely cited in all updated paediatric guidelines on cardiovascular prevention both in Europe and in US.

Publications

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Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium (2022)

International Journal of Obesity
Nuotio Joel, Laitinen Tomi T., Sinaiko Alan R., Woo Jessica G., Urbina Elaine M., Jacobs David R. Jr., Steinberger Julia, Prineas Ronald J., Sabin Matthew A., Burgner David P., Minn Heikki, Burns Trudy L., Bazzano Lydia A., Venn Alison J., Viikari Jorma S. A., Hutri-Kähönen Nina, Daniels Stephen R., Raitakari Olli T., Magnussen Costan G., Juonala Markus, Dwyer Terence
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals (2022)

Communications Biology
Winkler TW, Rasheed H, Teumer A, Gorski M, Rowan BX, Stanzick KJ, Thomas LF, Tin A, Hoppmann A, Chu AY, Tayo B, Thio CHL, Cusi D, Chai JF, Sieber KB, Horn K, Li M, Scholz M, Cocca M, Wuttke M, van der Most PJ, Yang Q, Ghasemi S, Nutile T, Li Y, Pontali G, Gunther F, Dehghan A, Correa A, Parsa A, Feresin A, de Vries APJ, Zonderman AB, Smith AV, Oldehinkel AJ, De Grandi A, Rosenkranz AR, Franke A, Teren A, Metspalu A, Hicks AA, Morris AP, Tonjes A, Morgan A, Podgornaia AI, Peters A, Korner A, Mahajan A, Campbell A, Freedman BI, Spedicati B, Ponte B, Schottker B, Brumpton B, Banas B, Kramer BK, Jung B, Asvold BO, Smith BH, Ning B, Penninx BWJH, Vanderwerff BR, Psaty BM, Kammerer CM, Langefeld CD, Hayward C, Spracklen CN, Robinson-Cohen C, Hartman CA, Lindgren CM, Wang CL, Sabanayagam C, Heng CK, Lanzani C, Khor CC, Cheng CY, Fuchsberger C, Gieger C, Shaffer CM, Schulz CA, Willer CJ, Chasman DI, Gudbjartsson DF, Ruggiero D, Toniolo D, Czamara D, Porteous DJ, Waterworth DM, Mascalzoni D, Mook-Kanamori DO, Reilly DF, Daw EW, Hofer E, Boerwinkle E, Salvi E, Bottinger EP, Tai ES, Catamo E, Rizzi F, Guo F, Rivadeneira F, Guilianini F, Sveinbjornsson G, Ehret G, Waeber G, Biino G, Girotto G, Pistis G, Nadkarni GN, Delgado GE, Montgomery GW, Snieder H, Campbell H, White HD, Gao H, Stringham HM, Schmidt H, Li HT, Brenner H, Holm H, Kirsten H, Kramer H, Rudan I, Nolte IM, Tzoulaki I, Olafsson I, Martins J, Cook JP, Wilson JF, Halbritter J, Felix JF, Divers J, Kooner JS, Lee JJM, O'Connell J, Rotter JI, Liu JJ, Xu J, Thiery J, Arnlov J, Kuusisto J, Jakobsdottir J, Tremblay J, Chambers JC, Whitfield JB, Gaziano JM, Marten J, Coresh J, Jonas JB, Mychaleckyj JC, Christensen K, Eckardt KU, Mohlke KL, Endlich K, Dittrich K, Ryan KA, Rice KM, Taylor KD, Ho K, Nikus K, Matsuda K, Strauch K, Miliku K, Hveem K, Lind L, Wallentin L, Yerges-Armstrong LM, Raffield LM, Phillips LS, Launer LJ, Lyytikainen LP, Lange LA, Citterio L, Klaric L, Ikram MA, Ising M, Kleber ME, Francescatto M, Concas MP, Ciullo M, Piratsu M, Orho-Melander M, Laakso M, Loeffler M, Perola M, de Borst MH, Gogele M, La Bianca M, Lukas MA, Feitosa MF, Biggs ML, Wojczynski MK, Kavousi M, Kanai M, Akiyama M, Yasuda M, Nauck M, Waldenberger M, Chee ML, Chee ML, Boehnke M, Preuss MH, Stumvoll M, Province MA, Evans MK, O'Donoghue ML, Kubo M, Kahonen M, Kastarinen M, Nalls MA, Kuokkanen M, Ghanbari M, Bochud M, Josyula NS, Martin NG, Tan NYQ, Palmer ND, Pirastu N, Schupf N, Verweij N, Hutri-Kahonen N, Mononen N, Bansal N, Devuyst O, Melander O, Raitakari OT, Polasek O, Manunta P, Gasparini P, Mishra PP, Sulem P, Magnusson PKE, Elliott P, Ridker PM, Hamet P, Svensson PO, Joshi PK, Kovacs P, Pramstaller PP, Rossing P, Vollenweider P, van der Harst P, Dorajoo R, Sim RZH, Burkhardt R, Tao R, Noordam R, Magi R, Schmidt R, de Mutsert R, Rueedi R, van Dam RM, Carroll RJ, Gansevoort RT, Loos RJF, Felicita SC, Sedaghat S, Padmanabhan S, Freitag-Wolf S, Pendergrass SA, Graham SE, Gordon SD, Hwang SJ, Kerr SM, Vaccargiu S, Patil SB, Hallan S, Bakker SJL, Lim SC, Lucae S, Vogelezang S, Bergmann S, Corre T, Ahluwalia TS, Lehtimaki T, Boutin TS, Meitinger T, Wong TY, Bergler T, Rabelink TJ, Esko T, Haller T, Thorsteinsdottir U, Volker U, Foo VHX, Salomaa V, Vitart V, Giedraitis V, Gudnason V, Jaddoe VWV, Huang W, Zhang WH, Wei WB, Kiess W, Marz W, Koenig W, Lieb W, Gao X, Sim XL, Wang YX, Friedlander Y, Tham YC, Kamatani Y, Okada Y, Milaneschi Y, Yu Z, Stark KJ, Stefansson K, Boger CA, Hung AM, Kronenberg F, Kottgen A, Pattaro C, Heid IM
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues (2022)

Epigenomics
Marttila Saara, Tamminen Hely, Rajić Sonja, Mishra Pashupati P, Lehtimäki Terho, Raitakari Olli, Kähönen Mika, Kananen Laura, Jylhävä Juulia, Hägg Sara, Delerue Thomas, Peters Annette, Waldenberger Melanie, Kleber Marcus E, März Winfried, Luoto Riitta, Raitanen Jani, Sillanpää Elina, Laakkonen Eija K, Heikkinen Aino, Ollikainen Miina, Raitoharju Emma
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies (2022)

Kidney International
Gorski Mathias, Rasheed Humaira, Teumer Alexander, Thomas Laurent F., Graham Sarah E., Sveinbjornsson Gardar, Winkler Thomas W., Günther Felix, Stark Klaus J., Chai Jin-Fang, Tayo Bamidele O., Wuttke Matthias, Li Yong, Tin Adrienne, Ahluwalia Tarunveer S., Ärnlöv Johan, Åsvold Bjørn Olav, Bakker Stephan J.L., Banas Bernhard, Bansal Nisha, Biggs Mary L., Biino Ginevra, Böhnke Michael, Boerwinkle Eric, Bottinger Erwin P., Brenner Hermann, Brumpton Ben, Carroll Robert J., Chaker Layal, Chalmers John, Chee Miao-Li, Chee Miao-Ling, Cheng Ching-Yu, Y.Chu Audrey, Ciullo Marina, Cocca Massimiliano, Cook James P., Coresh Josef, Cusi Daniele, de Borst Martin H., Degenhardt Frauke, Eckardt Kai-Uwe, Endlich Karlhans, Evans Michele K., Feitosa Mary F., Franke Andre, Freitag-Wolf Sandra, Fuchsberger Christian, Gampawar Piyush, Gansevoort Ron T., Ghanbari Mohsen, Ghasemi Sahar, Giedraitis Vilmantas, Gieger Christian, Gudbjartsson Daniel F., Hallan Stein, Hamet Pavel, Hishida Asahi, Ho Kevin, Hofer Edith, Holleczek Bernd, Holm Hilma, Hoppmann Anselm, Horn Katrin, Hutri-Kähönen Nina, Hveem Kristian, Hwang Shih-Jen, Ikram M. Arfan, Josyula Navya Shilpa, Jung Bettina, Kähönen Mika, Karabegović Irma, Khor Chiea-Chuen, Koenig Wolfgang, Kramer Holly, Krämer Bernhard K., Kühnel Brigitte, Kuusisto Johanna, Laakso Markku, Lange Leslie A., Lehtimäki Terho, Li Man, Lieb Wolfgang, Lind Lars, Lindgren Cecilia M., Loos Ruth J.F., Lukas Mary Ann, Lyytikäinen Leo-Pekka, Mahajan Anubha, Matias-Garcia Pamela R., Meisinger Christa, Meitinger Thomas, Melander Olle, Milaneschi Yuri, Mishra Pashupati P., Mononen Nina, Morris Andrew P., Mychaleckyj Josyf C., Nadkarni Girish N., Naito Mariko, Nakatochi Masahiro, Nalls Mike A., Nauck Matthias, Nikus Kjell, Ning Boting, Nolte Ilja M., Nutile Teresa, O’Donoghue Michelle L., O'Connell Jeffrey, Olafsson Isleifur, Orho-Melander Marju, Parsa Afshin, Pendergrass Sarah A., Penninx Brenda W.J.H., Pirastu Mario, Preuss Michael H., Psaty Bruce M., M.Raffield Laura, Raitakari Olli T., Rheinberger Myriam, Rice Kenneth M., Rizzi Federica, Rosenkranz Alexander R., Rossing Peter, Rotter Jerome I., Ruggiero Daniela, Ryan Kathleen A., Sabanayagam Charumathi, Salvi Erika, Schmidt Helena, Schmidt Reinhold, Scholz Markus, Schöttker Ben, Schulz Christina-Alexandra, Sedaghat Sanaz, Shaffer Christian M., Sieber Karsten B., Sim Xueling, Sims Mario, Snieder Harold, Stanzick Kira J., Thorsteinsdottir Unnur, Stocker Hannah, Strauch Konstantin, Stringham Heather M., Sulem Patrick, Szymczak Silke, Taylor Kent D., Thio Chris H.L., Tremblay Johanne, Vaccargiu Simona, van der Harst Pim, van der Most Peter J., Verweij Niek, Völker Uwe, Wakai Kenji, Waldenberger Melanie, Wallentin Lars, Wallner Stefan, Wang Judy, Waterworth Dawn M., White Harvey D., Willer Cristen J., Wong Tien-Yin, Woodward Mark, Yang Qiong, Yerges-Armstrong Laura M., Zimmermann Martina, Zonderman Alan B., Bergler Tobias, Stefansson Kari, Böger Carsten A., Pattaro Cristian, Köttgen Anna, Kronenberg Florian, Heid Iris M.; Lifelines Cohort Study
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )