Olli
Pentikäinen
Professor, Institute of Biomedicine
InFLAMES Flagship
PhD
Links
Areas of expertise
Computer-Dependent Drug Discovery
Molecular Modeling
Protein structure-function relationship
Protein-protein interaction
Biography
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Research
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
Publications
Detection of binding sites on SARS-CoV-2 Spike protein receptor-binding domain by molecular dynamics simulations in mixed solvents (2021)
IEEE/ACM Transactions on Computational Biology and Bioinformatics
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13 (2021)
Xenobiotica
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Coumarins as Tool Compounds to Aid the Discovery of Selective Function Modulators of Steroid Hormone Binding Proteins (2021)
Molecules
(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))
Negative Image-Based Screening: Rigid Docking Using Cavity Information (2021)
(Vertaisarvioitu artikkeli kokoomateoksessa (A3))Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling (2021)
ACS Omega
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
A holistic view on c-Kit in cancer: Structure, signaling, pathophysiology and its inhibitors (2021)
BBA - Reviews on Cancer
(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))
In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs (2020)
European Journal of Pharmaceutical Sciences
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Inhibition of human CYP1 enzymes by a classical inhibitor α-naphthoflavone and a novel inhibitor N-(3, 5-dichlorophenyl)cyclopropanecarboxamide: An in vitro and in silico study (2020)
Chemical Biology and Drug Design
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Screening of Natural Products Targeting SARS-CoV-2-ACE2 Receptor Interface - A MixMD Based HTVS Pipeline (2020)
Frontiers in Chemistry
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species (2020)
Xenobiotica
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))