Olena
Parilova
Biochemistry
MS
Contact
Links
Areas of expertise
RNA polymerase I
in vitro transcription
protein purification
structural biology
Research
I focus on the mechanism of transcription initiation by RNA polymerase I (Pol1). I study in vitro reconstituted Pol1 system from Saccharomyces cerevisiae as a model and elucidate its function using single molecule biophysical methods capable of real-time monitoring of proteins.
Publications
Real-Time Single-Molecule Studies of RNA Polymerase–Promoter Open Complex Formation Reveal Substantial Heterogeneity Along the Promoter-Opening Pathway (2022)
Journal of Molecular Biology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Structural basis for Acinetobacter baumannii biofilm formation (2018)
Proceedings of the National Academy of Sciences of the United States of America
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Archaic and alternative chaperones preserve pilin folding energy by providing incomplete structural information (2018)
Journal of Biological Chemistry
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))