Muhammad
Ashraf
Doctoral Researcher, Anaesthesiology, Intensive Care
M.Sc.
Contact
Links
Areas of expertise
Pharmacokinetics
Clinical Pharmacokinetics
Pharmacokinetic-Pharmacodynamic Modeling
Population PK/PD
Non-linear Mixed Effects Modeling
NONMEM
R
Clinical Pharmacokinetics
Pharmacokinetic-Pharmacodynamic Modeling
Population PK/PD
Non-linear Mixed Effects Modeling
NONMEM
R
Biography
Education:1. Ph.D. Drug Research Doctoral Programme (DRDP) 01/10/2016 - Present Department of Anesthesiology and Intensive Care, University of Turku, Turku, Finland.2. M.Sc. General Toxicology 01/09/2013 - 06/01/2016 University of Eastern Finland, Kuopio Finland.3. Doctor of Pharmacy (Pharm.D) 14/02/2007 - 30/04/2012 Riphah International University, Islamabad Pakistan.
Work Experience:1. Project Researcher 01/10/16 - Present Turku University Hospital, Turku Finland.2. Lecturer (Clinical Pharmacy/Biopharm and Pharmacokinetics) 14/02/12 - 01/08/13 University of Lahore, Islamabad Campus, Islamabad Pakistan.
Work Experience:1. Project Researcher 01/10/16 - Present Turku University Hospital, Turku Finland.2. Lecturer (Clinical Pharmacy/Biopharm and Pharmacokinetics) 14/02/12 - 01/08/13 University of Lahore, Islamabad Campus, Islamabad Pakistan.
Teaching
Pharmacology
Clinical Pharmacology
Pharmacokinetics
Population PK/PD Modeling
Research
I am working in the field of pharmacometrics, where I use the 'population approach' (i.e. non-linear mixed effects modeling) to describe the pharmacokinetic (PK) and/or pharmacokinetic-pharmacodynamic (PK-PD) behaviors of drugs in the human body. I am applying these concepts to data from ongoing clinical trials, that are being actively carried out at the Turku University Hospital, with anesthetic agents and pain medications. The rationale is to elucidate the optimal dosing schemes for these drugs for use in pain medicine, in an attempt to implement precision medicine in this area of medical care provision.
Publications
Population Pharmacokinetic Quantification of CYP2D6 Activity in Codeine Metabolism in Ambulatory Surgical Patients for Model-Informed Precision Dosing (2024)
Clinical Pharmacokinetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Population Modelling of Dexmedetomidine Pharmacokinetics and Haemodynamic Effects After Intravenous and Subcutaneous Administration (2020)
Clinical Pharmacokinetics
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Semimechanistic Population Pharmacokinetic Model to Predict the Drug–Drug Interaction Between S-ketamine and Ticlopidine in Healthy Human Volunteers (2018)
CPT: Pharmacometrics and Systems Pharmacology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))