The benefits of exercise in the treatment of diabetes have been advocated since as early as the 5th century. Most of the consensus is because exercise improves insulin sensitivity (mostly through its effects in the muscle). But just as the aetiology of diabetes is multifactorial, the beneficial effects of exercise cannot be attributed just to the changes in the muscle. Other organs (liver, pancreas and intestine) have been shown to also play an important role in the pathogenesis. Although much has been debated about the role of these organs in the pathogenesis of type 2 diabetes little attention has been directed towards how exercise affects these organs. I am particularly interested in understanding how the exercise-mediated signals affect these organs and how these interactions lead to improvements in the whole body metabolism. My research aims to answer these questions and it will be one of the first where the effects of exercise will be studied so extensively in humans and animals using modern molecular imaging techniques available. Furthermore, by measuring how liver, pancreas and intestine respond to different modes of exercise intensities in healthy and type 2 diabetic patients will provide new details for innovative interventions aimed at preventing diabetes and complications associated with it.