Jorma Toppari profile picture
Jorma
Toppari
Professor, Institute of Biomedicine
InFLAMES Flagship
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Links

CV_Jorma_Toppari_ 2018_Nov.pdf
Publications J Toppari 2018 Nov.pdf
ORCID

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

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Assuring safety without animal testing – The case for the human testis in vitro (2013)

The case for the human testis in vitro
Reproductive Toxicology
Chapin RE, Boekelheide K, Cortvrindt R, van Duursen MBM, Gant T, Jegou B, Marczylo E, van Pelt AMM, Post JN, Roelofs MJE, Schlatt S, Teerds KJ, Toppari J, Piersma AH
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Evidence for endocrine disruption in humans and wildlife (2013)

Jobling S, Bjerregaard P, Blumberg B, Brandt I, Brian JV, Casey SC, Frouin H, Giudice LC, Heindel JJ, Iguchi T, Kidd KA, Kortenkamp A, Lind M, Ropstad E, Ross PS, Skakkebaek NE, Toppari J, Woodruff TJ, Zoeller RT
(Vertaisarvioitu artikkeli kokoomateoksessa (A3))

Science and policy on endocrine disrupters must not be mixed: a reply to a "common sense" intervention by toxicology journal editors (2013)

Environmental Health: A Global Access Science Source
Bergman A, Andersson AM, Becher G, van den Berg M, Blumberg B, Bjerregaard P, Bornehag CG, Bornman R, Brandt I, Brian JV, Casey SC, Fowler PA, Frouin H, Giudice LC, Iguchi T, Hass U, Jobling S, Juul A, Kidd KA, Kortenkamp A, Lind M, Martin OV, Muir D, Ochieng R, Olea N, Norrgren L, Ropstad E, Ross PS, Ruden C, Scheringer M, Skakkebaek NE, Soder O, Sonnenschein C, Soto A, Swan S, Toppari J, Tyler CR, Vandenberg LN, Vinggaard AM, Wiberg K, Zoeller RT
(Kirjoitus tai data-artikkeli tieteellisessä aikakauslehdessä (B1))

PROKR2 mutations in autosomal recessive Kallmann syndrome (2013)

Fertility and Sterility
Tommiska J, Toppari J, Vaaralahti K, Kansakoski J, Laitinen EM, Noisa P, Kinnala A, Niinikoski H, Raivio T
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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