Jorma Toppari profile picture
Jorma
Toppari
Professor, Institute of Biomedicine
InFLAMES Flagship
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Links

CV_Jorma_Toppari_ 2018_Nov.pdf
Publications J Toppari 2018 Nov.pdf
ORCID

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

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Prospective virome analyses in young children at increased genetic risk for type 1 diabetes (2019)

Nature Medicine
Kendra Vehik, Kristian F. Lynch, Matthew C. Wong, Xiangjun Tian, Matthew C. Ross, Richard A. Gibbs, Nadim J. Ajami, Joseph F. Petrosino, Marian Rewers, Jorma Toppari, Anette G. Ziegler, Jin-Xiong She, Ake Lernmark, Beena Akolkar, William A. Hagopian, Desmond A. Schatz, Jeffrey P. Krischer, Heikki Hyöty, Richard E. Lloyd; the TEDDY Study Group
(Kirjoitus tai data-artikkeli tieteellisessä aikakauslehdessä (B1))

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes (2019)

Biomolecules
Lamichhane Santosh, Ahonen Linda, Dyrlund Thomas Spartholt, Dickens Alex M., Siljander Heli, Hyöty Heikki, Ilonen Jorma, Toppari Jorma, Veijola Riitta, Hyötyläinen Tuulia, Knip Mikael, Oresic Matej
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Antiandrogeenit (2019)

Ilpo Huhtaniemi, Jorma Toppari
(Artikkeli ammatillisessa kokoomateoksessa (D2))

Metabolite-related dietary patterns and the development of islet autoimmunity (2019)

Scientific Reports
Randi K. Johnson, Lauren Vanderlinden, Brian C . DeFelice, Katerina Kechris, Ulla Uusitalo, Oliver Fiehn, Marci Sontag, Tessa Crume, Andreas Beyerlein, Åke Lernmark, Jorma Toppari, Anette-G. Ziegler, Jin-Xiong She, William Hagopian, Marian Rewers, Beena Akolkar, Jeffrey Krischer, Suvi M. Virtanen, Jill M. Norris; & The TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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