Johanna Schleutker profile picture
Johanna
Schleutker
Professor, Institute of Biomedicine
PhD, Professor of Medical Genetics

Contact

+358 29 450 2726
+358 50 443 7237
Kiinamyllynkatu 10
20520
Turku

Areas of expertise

Cancer genetics
hereditary cancer
genomics
human genetics

Biography

Johanna Schleutker got her PhD in 1995 in University of Turku, Faculty of Medicine.The topic of her doctoral thesis was "Linkage disequilibrium is Salla disease; positioning of the sialic acid transport defect". She then moved to University of Tampere, and did her post doc in 1996-1998 in the Cancer Genetics research group of Professor Olli Kallioniemi. Her career continued in the US where she spent the years of 1999-2000 working as a research associate at the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD. During the NIH years, she studied genetics of familial prostate cancer in the group of Dr. Jeffrey M.Trent. After her return to Finland, Schleutker started her own research group in 2001 at the Insitute of Medical Technology, University of Tampere, and has ever since focused her studies on genetics and genetic susceptibility of prostate and breast cancer. Schleutker got a professorship in University of Tampere in 2008. In 2011 she started as a professor of medical genetics in University of Turku.

Teaching

Genetics, cancer genetics, hereditary cancer, genomics, molecular biology.

Research

The Schleutker group "Genetic Predisposition to Cancer" is studying both breast and prostate cancer genetics, the main emphasis being on prostate cancer. Of all cancers, prostate cancer (PrCa) has been reported as one of the most heritable diseases: genetic factors have been estimated to account for 57% of the risk. The goal is to identify and characterize predisposing genes and variants, especially those affecting aggressive outcome, including treatment responses to therapies. Further, the aim is to develop tools for prognostic purposes, i.e. prognostic biomarkers. The group has identified many significant genomic risk regions, candidate genes and variants, which have been then further profiled and characterized by functional studies. The group has produced (by 2021) 12 PhD degrees and published over 190 original, peer-reviewed articles in international journals.

Publications

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Runs of homozygosity and testicular cancer risk (2019)

Andrology
C. Loveday, A. Sud K. Litchfield, M. Levy, A. Holroyd, P. Broderick, Z. Kote‐Jarai, A. M. Dunning, K. Muir, J. Peto, R. Eeles, D. F. Easton, D. Dudakia, N. Orr, N. Pashayan; UK Testicular Cancer Collaboration; The PRACTICAL Consortium; A. Reid, R. A. Huddart, R. S. Houlston, C. Turnbull
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk: A Transcriptome-Wide Association Study in over 140,000 European Descendants (2019)

Cancer Research
Lang Wu, Jifeng Wang, Qiuyin Cai, Taylor B. Cavazos, Nima C. Emami, Jirong Long, Xiao-Ou Shu, Yingchang Lu, Xingyi Guo, Joshua A. Bauer, Bogdan Pasaniuc, Kathryn L. Penney, Matthew L. Freedman; and the PRACTICAL, CRUK; BPC3; CAPS; PEGASUS Consortia; Zsofia Kote-Jarai, John S. Witte, Christopher A. Haiman, Rosalind A. Eeles, Wei Zheng
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Syövän perinnöllisyys (2019)

Lääkärilehti
Kankuri-Tammilehto Minna, Vihinen Pia, Schleutker Johanna
(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))

Genetic architecture of human plasma lipidome and its link to cardiovascular disease (2019)

Nature Communications
Tabassum R, Ramo JT, Ripatti P, Koskela JT, Kurki M, Karjalainen J, Palta P, Hassan S, Nunez-Fontarnau J, Kiiskinen TTJ, Soderlund S, Matikainen N, Gerl MJ, Surma MA, Klose C, Stitziel NO, Laivuori H, Havulinna AS, Service SK, Salomaa V, Pirinen M, Jauhiainen M, Daly MJ, Freimer NB, Palotie A, Taskinen MR, Simons K, Ripatti S, Jalanko A, Kaprio J, Donner K, Kaunisto M, Mars N, Dada A, Shcherban A, Ganna A, Lehisto A, Kilpelainen E, Brein G, Awaisa G, Harju J, Parr K, Parolo PD, Kajanne R, Lemmela S, Sipila TP, Sipila T, Lyhs U, Llorens V, Niiranen T, Kristiansson K, Mannikko L, Jimenez MG, Perola M, Wong R, Kilpi T, Hiekkalinna T, Jarvensivu E, Kaiharju E, Mattsson H, Laukkanen M, Laiho P, Lahteenmaki S, Sistonen T, Soini S, Ziemann A, Lehtonen A, Lertratanakul A, Georgantas B, Riley-Gillis B, Quarless D, Rahimov F, Heap G, Jacob H, Waring J, Davis JW, Smaoui N, Popovic R, Esmaeeli S, Waring J, Matakidou A, Challis B, Close D, Petrovski S, Karlsson A, Schleutker J, Pulkki K, Virolainen P, Kallio L, Mannermaa A, Heikkinen S, Kosma VM, Chen CY, Runz H, Liu J, Bronson P, John S, Landenpera S, Eaton S, Zhou W, Hendolin M, Tuovila O, Pakkanen R, Maranville J, Usiskin K, Hochfeld M, Plenge R, Yang R, Biswas S, Greenberg S, Laakkonen E, Kononen J, Paloneva J, Kujala U, Kuopio T, Laukkanen J, Kangasniemi E, Savinainen K, Laaksonen R, Arvas M, Ritari J, Partanen J, Hyvarinen K, Wahlfors T, Peterson A, Oh D, Chang D, Teng E, Strauss E, Kerchner G, Chen H, Chen H, Schutzman J, Michon J, Hunkapiller J, McCarthy M, Bowers N, Lu T, Bhangale T, Pulford D, Waterworth D, Kulkarni D, Xu FL, Betts J, Gordillo JE, Hoffman J, Auro K, McCarthy L, Ghosh S, Ehm M, Pitkanen K, Makela T, Loukola A, Joensuu H, Sinisalo J, Eklund K, Aaltonen L, Farkkila M, Carpen O, Kauppi P, Tienari P, Ollila T, Tuomi T, Meretoja T, Pitkaranta A, Turunen J, Hannula-Jouppi K, Pikkarainen S, Seitsonen S, Koskinen M, Palomaki A, Rinne J, Metsarinne K, Elenius K, Pirila L, Koulu L, Voutilainen M, Juonala M, Peltonen S, Aaltonen V, Loboda A, Podgornaia A, Chhibber A, Chu A, Fox C, Diogo D, Holzinger E, Eicher J, Gormley P, Mehta V, Wang XL, Kettunen J, Pylkas K, Kalaoja M, Karjalainen M, Hinttala R, Kaarteenaho R, Vainio S, Mantere T, Remes A, Huhtakangas J, Junttila J, Tasanen K, Huilaja L, Luodonpaa M, Hautala N, Karihtala P, Kauppila S, Harju T, Blomster T, Soininen H, Harvima I, Pihlajamaki J, Kaarniranta K, Pelkonen M, Laakso M, Hiltunen M, Kiviniemi M, Kaipiainen-Seppanen O, Auvinen P, Kalviainen R, Julkunen V, Malarstig A, Hedman A, Marshal C, Whelan C, Lehtonen H, Parkkinen J, Linden K, Kalpala K, Miller M, Bing N, McDonough S, Chen X, Hu XL, Wu Y, Auranen A, Jussila A, Uusitalo-Jarvinen H, Kankaanranta H, Uusitalo H, Peltola J, Kahonen M, Isomaki P, Laitinen T, Salmi T, Muslin A, Wang C, Chatelain C, Xu E, Auge F, Call K, Klinger K, Crohns M, Gossel M, Palin K, Rivas M, Siirtola H, Tabuenca JG
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Association analyses identify 31 new risk loci for colorectal cancer susceptibility (2019)

Nature Communications
Law PJ, Timofeeva M, Fernandez-Rozadilla C, Timofeeva A, Broderick P, Studd J, Fernandez-Tajes J, Farrington S, Svinti V, Palles C, Orlando G, Sud A, Holroyd A, Penegar S, Theodoratou E, Vaughan-Shaw P, Campbell H, Zgaga L, Hayward C, Campbell A, Harris S, Deary IJ, Starr O, Gatcombe L, Pinna M, Briggs S, Martin L, Jaeger E, Sharma-Oates A, East J, Leedham S, Arnold R, Johnstone E, Wang H, Kerr D, Kerr R, Maughan T, Kaplan R, Al-Tassan N, Palin K, Hanninen UA, Cajuso T, Tanskanen T, Kondelin J, Kaasinen E, Sarin AP, Eriksson JG, Rissanen H, Knekt P, Pukkala E, Jousilahti P, Salomaa V, Ripatti S, Palotie A, Renkonen-Sinisalo L, Lepisto A, Bohm J, Mecklin JP, Buchanan DD, Win AK, Hopper J, Jenkins ME, Lindor NM, Newcomb PA, Gallinger S, Duggan D, Casey G, Hoffmann P, Nothen MM, Jockel KH, Easton DF, Pharoah PDP, Peto J, Canzian F, Swerdlow A, Eeles RA, Kote-Jarai Z, Muir K, Pashayan N, Harkin A, Allan K, McQueen J, Paul J, Iveson T, Saunders M, Butterbach K, Chang-Claude J, Hoffmeister M, Brenner H, Kirac I, Matosevic P, Hofer P, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Houlston RS, Dunlop MG, Henderson BE, Haiman CA, Schumacher FR, Al Olama AA, Benlloch S, Berndt SI, Conti DV, Wiklund F, Chanock S, Gapstur S, Stevens VL, Tangen CM, Batra J, Clements J, Gronberg H, Schleutker J, Albanes D, Wolk A, West C, Mucci L, Cancel-Tassin G, Koutros S, Sorensen KD, Grindeda EM, Neal DE, Hamdy FC, Donovan JL, Travis RC, Hamilton RJ, Ingles SA, Rosenstein BS, Lu YJ, Giles GG, Kibel AS, Vega A, Kogevinas M, Penney KL, Park JY, Stanford JL, Cybulski C, Nordestgaard BG, Maier C, Kim J, John EM, Teixeira MR, Neuhausen SL, De Ruyck K, Razack A, Newcomb LF, Gamulin M, Kaneva R, Usmani N, Claessens F, Townsend PA, Gago-Dominguez M, Roobol MJ, Menegaux F, Khaw KT, Cannon-Albright L, Pandha H, Thibodeau SN
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study (2019)

Cancer Epidemiology, Biomarkers and Prevention
Charleen D. Adams, Rebecca Richmond, Diana L. Santos Ferreira, Wes Spiller, Vanessa Tan, Jie Zheng, Peter Würtz, Jenny Donovan, Freddie Hamdy, David Neal, J. Athene Lane, George Davey Smith, Caroline Relton, Rosalind A. Eeles, Christopher A. Haiman, ZSofia Kote-Jarai, Fredrick R. Schumacher, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Sonja I. Berndt, David V. Conti, Fredrik Wiklund, Stephen J. Chanock, Susan Gapstur, Victoria L. Stevens, Catherine M. Tangen, Jyotsna Batra, Judith A. Clements, Henrik Gronberg, Nora Pashayan, Johanna Schleutker, Demetrius Albanes, Alicja Wolk, Catharine M.L. West, Lorelei A. Mucci, Géraldine Cancel-Tassin, Stella Koutros, Karina Dalsgaard Sorensen, Lovise Maehle, Ruth C. Travis, Robert J. Hamilton, Sue Ann Ingles, Barry S. Rosenstein, Yong-Jie Lu, Graham G. Giles, Adam S. Kibel, Ana Vega, Manolis Kogevinas, Kathryn L. Penney, Jong Y. Park, Janet L. Stanford, Cezary Cybulski, Børge G. Nordestgaard, Hermann Brenner, Christiane Maier, Jeri Kim, Esther M. John, Manuel R. Teixeira, Susan L. Neuhausen, Kim De Ruyck, Azad Razack, Lisa F. Newcomb, Davor Lessel, Radka P. Kaneva, Nawaid Usmani, Frank Claessens, Paul A. Townsend, Manuela Gago Dominguez, Monique J. Roobol, Florence Menegaux, Kay-Tee Khaw, Lisa A. Cannon-Albright, Hardev Pandha, Stephen N. Thibodeau; on behalf of the PRACTICAL consortium, Richard M. Martin
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Oligogenic basis of sporadic ALS The example of SOD1 p.Ala90Val mutation (2019)

Neurology-Genetics
Liina Kuuluvainen, Karri Kaivola, Saana Mönkäre, Hannu Laaksovirta, Manu Jokela, Bjarne Udd, Miko Valori, Petra Pasanen, Anders Paetau, Bryan J. Traynor, David J. Stone, Johanna Schleutker, Minna Pöyhönen, Pentti J. Tienari, Liisa Myllykangas
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Recurrent moderate-risk mutations in Finnish breast and ovarian cancer patients (2019)

International Journal of Cancer
Anna Nurmi, Taru A. Muranen, Liisa M. Pelttari, Johanna I. Kiiski, Tuomas Heikkinen, Sini Lehto, Anne Kallioniemi, Johanna Schleutker, Ralf Bützow, Carl Blomqvist, Kristiina Aittomäki, Heli Nevanlinna
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Germline variation at 8q24 and prostate cancer risk in men of European ancestry (2018)

Nature Communications
Matejcic M, Saunders EJ, Dadaev T, Brook MN, Wang K, Sheng X, Al Olama AA, Schumacher FR, Ingles SA, Govindasami K, Benlloch S, Berndt SI, Albanes D, Koutros S, Muir K, Stevens VL, Gapstur SM, Tangen CM, Batra J, Clements J, Gronberg H, Pashayan N, Schleutker J, Wolk A, West C, Mucci L, Kraft P, Cancel-Tassin G, Sorensen KD, Maehle L, Grindedal EM, Strom SS, Neal DE, Hamdy FC, Donovan JL, Travis RC, Hamilton RJ, Rosenstein B, Lu YJ, Giles GG, Kibel AS, Vega A, Bensen JT, Kogevinas M, Penney KL, Park JY, Stanford JL, Cybulski C, Nordestgaard BG, Brenner H, Maier C, Kim J, Teixeira MR, Neuhausen SL, De Ruyck K, Razack A, Newcomb LF, Lessel D, Kaneva R, Usmani N, Claessens F, Townsend PA, Dominguez MG, Roobol MJ, Menegaux F, Khaw KT, Cannon-Albright LA, Pandha H, Thibodeau SN, Schaid DJ, Wiklund F, Chanock SJ, Easton DF, Eeles RA, Kote-Jarai Z, Conti DV, Haiman CA
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))