Heli Harvala profile picture
Heli
Harvala
Professor, Institute of Biomedicine
PhD, MSc, EUPHEM Alumni, FRCPath

Areas of expertise

Virology
Clinical Virology
Public Health Virology
Transfusion Virology

Biography

Heli Harvala was appointed as a Professor of Virology at the Institute of Biomedicine, University of Turku, Finland in September, 2024. 

She graduated in Medicine, obtained a MSc in Organic Chemistry and a PhD in Virology at the University of Turku, Finland, in 2003. Subsequently she completed her Medical Virology training in Edinburgh and became a Fellow of the Royal College of Pathologists in 2015. During that time, she joined the European Public Health Microbiology fellowship programme at the Public Health Agency of Sweden for two years before returning back to the UK. Over the last ten years, she has combined her work as a Consultant Medical Virologist with clinical, transfusion and public health related virology research.

Teaching

She is currently involved in the undergraduate teaching of medical and biomedical students, being responsible for the virology part of that. She has previously been involved in the Undergraduate teaching at the University College of London, University of Edinburgh, the University of Oulu and at the University of Turku. She is also actively engaging with Postgraduate teaching by supervising both PhD and MSc students, and has undertaken PhD Supervisors training at the University of Oxford. Furthermore, she has extensive experience in Clinical Virology specialty training; she has been trained educational supervisor in Clinical Virology since 2016 and trained Royal College of Pathologist Examiner in Clinical Virology since 2017.

Her interest includes developing training further and as an example, she developed a new three-day module in Phylogenetics and Bioinformatics for European Centre for Disease Control (ECDC) Stockholm with the microbiological cases studies in 2016. Subsequently, she led the developing and delivering this for the ECDC summer schools in Stockholm, 2016 and 2017, and for the ECDC EPIET/EUPHEM fellows in Berlin, 2017 and 2018.

    Research

    She is a co-founder of the European Non-Polio Enterovirus Network (ENPEN) which evaluates the importance of enterovirus infections and monitors for their emergence together with collaborators from over 30 European countries. During COVID-19 pandemic, she was involved with setting up SARS-CoV-2 testing of convalescent plasma donors in England, and the related international REMAP-CAP trial. She also has wide interests in molecular epidemiology and next generation sequencing, and is involved with investigations into how next generation sequencing could be used to enhance the effectiveness of microbiological donation screening.

    She leads the Blood Safety research team within the NIHR funded Blood and Transplant Research Unit at the University of Oxford. This research focuses on transfusion transmitted viral infections aiming to improve our understanding of current risks and preparedness for emerging pathogens. She also recently led the work in identifying occult hepatitis B infections as a blood transfusion risk in England and has done pioneering work to investigate pre-exposure prophylaxis use among syphilis infected blood donors. While these activieis continue, she is currently establishing her research group at the University of Turku.

    Prof Harvala is widely published in the field of medical, transfusion and public health virology (over 130 peer reviewed publications, h-index 48). She is an executive committee member of European Society for Clinical Virology and the programme committee member for the European Society for Clinical Microbiology and infectious Diseases. She was recently appointed to the WHO European Region Commission for the Certification of Poliomyelitis Eradication, and previously chaired the WHO R&D Blueprint group on Picornaviruses, the Microbiology Specialist Interest Group for the British Blood Transfusion Society, the Panel of Senior Virology Examiners for the RCPath and the Standing Advisory Committee for Transfusion Transmitted Infections.   

    Publications

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    Molecular epidemiology and evolutionary trajectory of emerging echovirus 30, Europe (2021)

    Emerging Infectious Diseases
    Benschop Kimberley S.M., Broberg Eeva, Hodcroft Emma, Schmitz Dennis, Albert Jan, Baicus Anda, Bailly Jean,Luc, Baldvinsdottir Gudrun, Berginc Natasa, Blomqvist Soile, Böttcher Sindy, Brytting Mia, Bujaki Erika, Cabrerizo Maria, Celma Cristina, Cinek Ondrej, Claas Eric C.J., Cremer Jeroen, Dean Jonathan, Dembinski Jennifer, Demchyshyna Iryna, Diedrich Sabine, Dudman Susanne, Dunning Jake, Dyrdak Robert, Emmanouil Mary, Farkas Agnes, De Gascun Cillian, Fournier Guillme, Georgieva Irina, Gonzalez Sanz Ruben, van Hooydonk Elving Jolanda, Jääskeläinen Anne, Jancskaite Ruta, Keeren Kathrin, Fischer Thea, Krokstad Sidsel, Nikolaeva-Glomb Lubomira, Novakova Ludmila, Midgley Sofie, Mirand Drey, Molenkamp Richard, Morley Ursula, Mossong Joël, Muralyte Svajune, Murk Jean,Luc, Nguyen Trung, Nordbø Svein, Österback Riikka, Pas Suzan, Pellegrinelli Lra, Pogka Vassiliki, Prochazka Birgit, Rainetova Petra, Van Ranst Marc, Roorda Lieuwe, Schuffenecker Isabelle, Schuurman Rob, Stoyanova Asya, Templeton Kate, Verweij Jaco, Voulgari,Kokota Androniki, Vuorinen Tytti, Wollants Elke, Wolthers Katja, Zakikhany Katherina, Neher Richard, Harvala Heli, Simmonds Peter
    (A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

    Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021 (2021)

    Eurosurveillance
    Benschop Kimberley SM, Albert Jan, Anton Andres, Andrés Cristina, Aranzamendi Maitane, Armannsdóttir Brynja, Bailly Jean-Luc, Baldanti Fausto, Baldvinsdóttir Guðrún Erna , Beard Stuart, Berginc Natasa, Böttcher Sindy, Blomqvist Soile, Bubba Laura, Calvo Cristina, Cabrerizo Maria, Cavallero Annalisa, Celma Cristina, Ceriotti Ferruccio, Costa Inês, Cottrell Simon, del Cuerpo Margarita, Dean Jonathan, Dembinski Jennifer L, Diedrich Sabine, Diez-Domingo Javier, Dorenberg DagnyHaug, Duizer Erwin, Dyrdak Robert, Fanti Diana, Farkas Agnes, Feeney Susan, Flipse Jacky, De Gascun Cillian, Galli Cristina, Georgieva Irina, Gifford Laura, Guiomar Raquel, Hönemann Mario, Ikonen Niina, Jeannoël Marion, Josset Laurence, Keeren Kathrin, López-Labrador F Xavier, Maier Melanie, McKenna James, Meijer Adam, Mengual-Chuliá Beatriz, Midgley Sofie E, Mirand Audrey, Montes Milagrosa, Moore Catherine, Morley Ursula, Murk Jean-Luc, Nikolaeva-Glomb Lubomira, Numanovic Sanela, Oggioni Massimo, Palminha Paula, Pariani Elena, Pellegrinelli Laura, Piralla Antonio, Pietsch Corinna, Piñeiro Luis, Rabella Núria, Rainetova Petra, Renteria Sara Colonia Uceda, Romero María P, Reynders Marijke, Roorda Lieuwe, Savolainen-Kopra Carita, Schuffenecker Isabelle, Soynova Aysa, Caroline MA Swanink, Ursic Tina, Verweij Jaco J, Vila Jorgina, Vuorinen Tytti, Simmonds Peter, Fischer Thea K, Harvala Heli
    (A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

    Recommendations for the introduction of metagenomic high-throughput sequencing in clinical virology, part I: Wet lab procedure (2021)

    Journal of Clinical Virology
    López-Labrador F. Xavier, Brown Julianne R., Fischer Nicole, Harvala Heli, Van Boheemen Sander, Cinek Ondrej, Sayiner Arzu, Madsen Tina Vasehus, Auvinen Eeva, Kufner Verena, Huber Michael, Rodriguez Christophe, Jonges Marcel, Hönemann Mario, Susi Petri, Sousa Hugo, Klapper Paul E., Pérez-Cataluňa Alba, Hernandez Marta, Molenkamp Richard, van der Hoek Lia, Schuurman Rob, Couto Natacha, Leuzinger Karoline, Simmonds Peter, Beer Martin, Höper Dirk, Kamminga Sergio, Feltkamp Mariet C.W., Rodríguez-Díaz Jesús, Keyaerts Els, Nielsen Xiaohui Chen, Puchhammer-Stöckl Elisabeth, Kroes Aloys C.M., Buesa Javier, Breuer Judy, Claas Eric C.J., de Vries Jutte J.C.; on behalf of the ESCV Network on Next-Generation Sequencing
    (A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

    A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts (2020)

    Journal of Medical Virology
    Hayes A, Nguyen D, Andersson M, Anton A, Bailly JL, Beard S, Benschop KSM, Berginc N, Blomqvist S, Cunningham E, Davis D, Dembinski JL, Diedrich S, Dudman SG, Dyrdak R, Eltringham GJA, Gonzales-Goggia S, Gunson R, Howson-Wells HC, Jaaskelainen AJ, Lopez-Labrador FX, Maier M, Majumdar M, Midgley S, Mirand A, Morley U, Nordbo SA, Oikarinen S, Osman H, Papa A, Pellegrinelli L, Piralla A, Rabella N, Richter J, Smith M, Strand AS, Templeton K, Vipond B, Vuorinen T, Williams C, Wollants E, Zakikhany K, Fischer TK, Harvala H, Simmonds P
    (A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

    Recommendations for enterovirus diagnostics and characterisation within and beyond Europe (2018)

    Journal of Clinical Virology
    Harvala H, Broberg E, Benschop K, Berginc N, Ladhani S, Susi P, Christiansen C, McKenna J, Allen D, Makiello P, McAllister G, Carmen M, Zakikhany K, Dyrdak R, Nielsen X, Madsen T, Paul J, Moore C, von Eije K, Piralla A, Carlier M, Vanoverschelde L, Poelman R, Anton A, Lopez-Labrador FX, Pellegrinelli L, Keeren K, Maier M, Cassidy H, Derdas S, Savolainen-Kopra C, Diedrich S, Nordbo S, Buesa J, Bailly JL, Baldanti F, MacAdam A, Mirand A, Dudman S, Schuffenecker I, Kadambari S, Neyts J, Griffiths MJ, Richter J, Margaretto C, Govind S, Morley U, Adams O, Krokstad S, Dean J, Pons-Salort M, Prochazka B, Cabrerizo M, Majumdar M, Nebbia G, Wiewel M, Cottrell S, Coyle P, Martin J, Moore C, Midgley S, Horby P, Wolthers K, Simmonds P, Niesters H, Fischer TK
    (A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)

    Development and Assay of RNA Transcripts of Enterovirus Species A to D, Rhinovirus Species A to C, and Human Parechovirus: Assessment of Assay Sensitivity and Specificity of Real-Time Screening and Typing Methods (2012)

    Journal of Clinical Microbiology
    McLeish NJ, Witteveldt J, Clasper L, McIntyre C, Leitch ECM, Hardie A, Bennett S, Gunson R, Carman WF, Feeney SA, Coyle PV, Vipond B, Muir P, Benschop K, Wolthers K, Waris M, Osterback R, Johannessen I, Templeton K, Harvala H, Simmonds P
    (A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )